ArticleNeuro-oncology2020
Resting-state fMRI detects alterations in whole brain connectivity related to tumor biology in glioma patients.
Article in Neuro-oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers, 2 of them syntheses that pooled it.
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Who cites it
86 citing papers in PubMed, 2 syntheses or guidelines pooled it, 127 citations in OpenAlex.
- Influences on cognitive outcomes in adult patients with gliomas: A systematic review.Frontiers in oncology · 2022Pooled it
- Isocitrate Dehydrogenase, Patient-Reported Outcomes, and Cognitive Functioning of Glioma Patients: a Systematic Review.Current oncology reports · 2020Pooled it
- Intratumoral and Peritumoral Functional Connectivity Reveals Network-Level Signatures of Glioma.MedComm · 2026Article
- From Anatomy to Outcome: Linking Glioma Location Patterns to Survival Using Non-Negative Matrix Factorization.Clinical neuroradiology · 2026Article
- Brain dysconnectivity patterns associated with chronic back pain development.Brain informatics · 2026Article
- Subcortical and Cerebellar Compensation for Motor Control in Medial Frontal Glioblastoma: A Task-Based Connectivity Study.Brain topography · 2026Article
- Multimodal network localization of brain abnormalities and neuromodulation target identification in obsessive-compulsive disorder.Scientific reports · 2026Article
- Anomaly Detection for Structural and Functional Connectivity in Glioma Patients.NMR in biomedicine · 2026Article
- A non-local diffusion magnetic resonance imaging tract density biomarker to stratify, predict, and interpret survival rates in human glioblastoma.Neuro-oncology · 2026Article
- A Machine Learning-Driven Electrophysiological Platform for Real-Time Tumor-Neural Interaction Analysis and Modulation.Nature communications · 2026Article
- BOLD complexity characterizes glioblastoma survival via voxel-wise and localized sample entropy.Journal of neuro-oncology · 2026Article
- The evolution of phonemic verbal fluency test: bridging tradition with contemporary insights.Frontiers in psychology · 2026Review
- Postsurgical perilesional functional connectivity predicts neurological outcome in glioma patients.Frontiers in neuroscience · 2026Article
- Glioma-related epilepsy in patients with newly diagnosed and recurrent glioblastoma, IDH-wildtype: a study under the 2021 WHO CNS tumor classification.BMC cancer · 2025Article
- Longitudinal Cerebral Structural, Microstructural, and Functional Alterations After Brain Tumor Surgery for Early Detection of Recurrent Tumors.Biomedicines · 2025Article
- Reducing functional dysconnectivity in people with schizophrenia spectrum disorders.BJPsych open · 2025Article
- Structural-functional fingerprinting for abnormalities investigation in glioma patients.Scientific reports · 2025Article
- The impact of glioblastoma on the contralesional hemisphere: insights from structural connectivity and cortical surface analysis.Neuroradiology · 2025Article
- High peritumoral network connectedness in glioblastoma reveals a distinct epigenetic signature and is associated with decreased overall survival.Neuro-oncology · 2025Article
- Predicting attention deficits and functional recovery after glioma resection through functional executive networks: insights from dynamic properties.Journal of neuro-oncology · 2025Article
26 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 3 countries.
Funding
Abstract
backgroundSystemic infiltration of the brain by tumor cells is a hallmark of glioma pathogenesis which may cause disturbances in functional connectivity. We hypothesized that aggressive high-grade tumors cause more damage to functional connectivity than low-grade tumors.
methodsWe designed an imaging tool based on resting-state functional (f)MRI to individually quantify abnormality of functional connectivity and tested it in a prospective cohort of patients with newly diagnosed glioma.
resultsThirty-four patients were analyzed (World Health Organization [WHO] grade II, n = 13; grade III, n = 6; grade IV, n = 15; mean age, 48.7 y). Connectivity abnormality could be observed not only in the lesioned brain area but also in the contralateral hemisphere with a close correlation between connectivity abnormality and aggressiveness of the tumor as indicated by WHO grade. Isocitrate dehydrogenase 1 (IDH1) mutation status was also associated with abnormal connectivity, with more alterations in IDH1 wildtype tumors independent of tumor size. Finally, deficits in neuropsychological performance were correlated with connectivity abnormality.
conclusionHere, we suggested an individually applicable resting-state fMRI marker in glioma patients. Analysis of the functional connectome using this marker revealed that abnormalities of functional connectivity could be detected not only adjacent to the visible lesion but also in distant brain tissue, even in the contralesional hemisphere. These changes were associated with tumor biology and cognitive function. The ability of our novel method to capture tumor effects in nonlesional brain suggests a potential clinical value for both individualizing and monitoring glioma therapy.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.