Evidence map›Paper›PMID 32107379›Full record

ArticleNature communications2020

A comparative genomics study of 23 Aspergillus species from section Flavi.

Inge Kjærbølling, Tammi Vesth, Jens C Frisvad, Jane L Nybo, Sebastian Theobald, Sara Kildgaard, Thomas Isbrandt Petersen, Alan Kuo, Atsushi Sato, Ellen K Lyhne and 27 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 113 papers.

0numbers the graph read from it
0cells of the map it votes in
113citing papers in PubMed
29.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

113 citing papers in PubMed, 205 citations in OpenAlex.

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  15. Unravelling the Functional Diversity of Type III Polyketide Synthases in Fungi.Angewandte Chemie (International ed. in English) · 2025
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  16. Article
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  19. Article
  20. Review

53 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

37 authors at 10 institutions in 6 countries.

Inge KjærbøllingDepartment of Biotechnology and Bioengineering, Technical University of Denmark, Søltoft Plads 223, 2800, Kongens Lyngby, Denmark.
Tammi VesthDepartment of Biotechnology and Bioengineering, Technical University of Denmark, Søltoft Plads 223, 2800, Kongens Lyngby, Denmark.
Jens C FrisvadDepartment of Biotechnology and Bioengineering, Technical University of Denmark, Søltoft Plads 223, 2800, Kongens Lyngby, Denmark.ORCID http://orcid.org/0000-0002-0573-4340
Jane L NyboDepartment of Biotechnology and Bioengineering, Technical University of Denmark, Søltoft Plads 223, 2800, Kongens Lyngby, Denmark.
Sebastian TheobaldDepartment of Biotechnology and Bioengineering, Technical University of Denmark, Søltoft Plads 223, 2800, Kongens Lyngby, Denmark.
Sara KildgaardDepartment of Biotechnology and Bioengineering, Technical University of Denmark, Søltoft Plads 223, 2800, Kongens Lyngby, Denmark.
Thomas Isbrandt PetersenDepartment of Biotechnology and Bioengineering, Technical University of Denmark, Søltoft Plads 223, 2800, Kongens Lyngby, Denmark.
Alan KuoUS Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA, 94598, USA.
Atsushi SatoKikkoman Corporation, 250 Noda, 278-0037, Noda, Japan.
Ellen K LyhneDepartment of Biotechnology and Bioengineering, Technical University of Denmark, Søltoft Plads 223, 2800, Kongens Lyngby, Denmark.
Martin E KogleDepartment of Biotechnology and Bioengineering, Technical University of Denmark, Søltoft Plads 223, 2800, Kongens Lyngby, Denmark.
Ad WiebengaFungal Physiology, Westerdijk Fungal Biodiversity Institute & Fungal Molecular Physiology, Utrecht University, Uppsalalaan 8, 3584 CT, Utrecht, The Netherlands.
Roland S KunFungal Physiology, Westerdijk Fungal Biodiversity Institute & Fungal Molecular Physiology, Utrecht University, Uppsalalaan 8, 3584 CT, Utrecht, The Netherlands.
Ronnie J M LubbersFungal Physiology, Westerdijk Fungal Biodiversity Institute & Fungal Molecular Physiology, Utrecht University, Uppsalalaan 8, 3584 CT, Utrecht, The Netherlands.
Miia R MäkeläDepartment of Microbiology, Faculty of Agriculture and Forestry, University of Helsinki, Viikinkaari 9, Helsinki, Finland.ORCID http://orcid.org/0000-0003-0771-2329
Kerrie BarryUS Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA, 94598, USA.
Mansi ChovatiaUS Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA, 94598, USA.
Alicia ClumUS Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA, 94598, USA.
Chris DaumUS Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA, 94598, USA.
Sajeet HaridasUS Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA, 94598, USA.ORCID http://orcid.org/0000-0002-0229-0975
Guifen HeUS Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA, 94598, USA.
Kurt LaButtiUS Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA, 94598, USA.ORCID http://orcid.org/0000-0002-5838-1972
Anna LipzenUS Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA, 94598, USA.
Stephen MondoUS Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA, 94598, USA.
Jasmyn PangilinanUS Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA, 94598, USA.
Robert RileyUS Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA, 94598, USA.
Asaf SalamovUS Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA, 94598, USA.
Blake A SimmonsUS Department of Energy Joint BioEnergy Institute, 5885 Hollis St., Emeryville, CA, 94608, USA.ORCID http://orcid.org/0000-0002-1332-1810
Jon K MagnusonUS Department of Energy Joint BioEnergy Institute, 5885 Hollis St., Emeryville, CA, 94608, USA.ORCID http://orcid.org/0000-0001-7712-7024
Bernard HenrissatArchitecture et Fonction des Macromolécules Biologiques, (CNRS UMR 7257, Aix-Marseille University, 163 Avenue de Luminy, Parc Scientifique et Technologique de Luminy, 13288, Marseille, France.
Uffe H MortensenDepartment of Biotechnology and Bioengineering, Technical University of Denmark, Søltoft Plads 223, 2800, Kongens Lyngby, Denmark.ORCID http://orcid.org/0000-0002-7794-7273
Thomas O LarsenDepartment of Biotechnology and Bioengineering, Technical University of Denmark, Søltoft Plads 223, 2800, Kongens Lyngby, Denmark.ORCID http://orcid.org/0000-0002-3362-5707
Ronald P de VriesFungal Physiology, Westerdijk Fungal Biodiversity Institute & Fungal Molecular Physiology, Utrecht University, Uppsalalaan 8, 3584 CT, Utrecht, The Netherlands.ORCID http://orcid.org/0000-0002-4363-1123
Igor V GrigorievUS Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA, 94598, USA.ORCID http://orcid.org/0000-0002-3136-8903
Masayuki MachidaKanazawa Institute of Technology, 3 Chome-1, 924-0838 Yatsukaho, Hakusan-shi, Ishikawa-ken, Japan.
Scott E BakerUS Department of Energy Joint BioEnergy Institute, 5885 Hollis St., Emeryville, CA, 94608, USA.ORCID http://orcid.org/0000-0001-5085-3106
Mikael R AndersenDepartment of Biotechnology and Bioengineering, Technical University of Denmark, Søltoft Plads 223, 2800, Kongens Lyngby, Denmark. MRRA@novozymes.com.ORCID http://orcid.org/0000-0003-4794-6808
Joint Genome Institute · USTechnical University of Denmark · DKUtrecht University · NLJoint BioEnergy Institute · USCentre National de la Recherche Scientifique · FRKanazawa Institute of Technology · JPKikkoman (Japan) · JPNovozymes (Denmark) · DKPacific Northwest National Laboratory · USUniversity of Helsinki · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Section Flavi encompasses both harmful and beneficial Aspergillus species, such as Aspergillus oryzae, used in food fermentation and enzyme production, and Aspergillus flavus, food spoiler and mycotoxin producer. Here, we sequence 19 genomes spanning section Flavi and compare 31 fungal genomes including 23 Flavi species. We reassess their phylogenetic relationships and show that the closest relative of A. oryzae is not A. flavus, but A. minisclerotigenes or A. aflatoxiformans and identify high genome diversity, especially in sub-telomeric regions. We predict abundant CAZymes (598 per species) and prolific secondary metabolite gene clusters (73 per species) in section Flavi. However, the observed phenotypes (growth characteristics, polysaccharide degradation) do not necessarily correlate with inferences made from the predicted CAZyme content. Our work, including genomic analyses, phenotypic assays, and identification of secondary metabolites, highlights the genetic and metabolic diversity within section Flavi.

Indexed as

GenomicsAspergillus flavusAspergillus oryzaeBioreactorsCarbohydrate MetabolismCrops, AgriculturalDNA, FungalFermentationFermented FoodsFungal ProteinsGenome, FungalMetabolic Networks and PathwaysMultigene FamilyPhenotypePhylogenyPlant DiseasesDNA, FungalFungal Proteins

Identifiers

PMID32107379
PMCPMC7046712
OpenAlexW3010606899

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.