ArticleNeurobiology of aging2020
Choroid plexus volume is associated with levels of CSF proteins: relevance for Alzheimer's and Parkinson's disease.
Article in Neurobiology of aging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
86 citing papers in PubMed, 3 syntheses or guidelines pooled it, 141 citations in OpenAlex.
- Choroid plexus volume in Alzheimer's disease: A systematic review and meta-analysis.Journal of Alzheimer's disease : JAD · 2026Pooled it
- Choroid plexus volume in brain disorders: a systematic review.Fluids and barriers of the CNS · 2025Pooled it
- Choroid plexus volume in multiple sclerosis: a systematic review and meta-analysis of an emerging imaging biomarker.European journal of medical research · 2025Pooled it
- The impaired hemodynamics of choroid plexus and its interactions within the glymphatic system in Parkinson's disease.GeroScience · 2026Article
- Regional choroid plexus calcifications and their associations with aging, brain structure, and disease.bioRxiv : the preprint server for biology · 2026Article
- Choroid Plexus Microstructural Alterations Link Glymphatic Dysfunction and White Matter Degeneration in Parkinson's Disease.CNS neuroscience & therapeutics · 2026Article
- Article
- The role of glymphatic-related structural and functional imaging biomarkers in the pathological progression of Alzheimer's disease: a multimodal imaging-based study.Quantitative imaging in medicine and surgery · 2026Article
- Peripheral inflammation impairs glymphatic function, contributing to neurodegeneration in Alzheimer's disease.iScience · 2026Article
- Divergent Glymphatic Dysfunction and Free Water Pathology Underpin Distinct Mechanisms and Enable Differential Diagnosis in Parkinson's Disease and Multiple System Atrophy.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- Enlarged choroid plexus in chronic insomnia patients and its association with DTI-ALPS index alterations and cognitive decline.Neuroradiology · 2026Article
- Associations of DTI-ALPS index and choroid plexus volume with clinical severity across the Parkinson's disease spectrum.NPJ Parkinson's disease · 2026Article
- Choroid plexus remodeling linked to impaired CSF-mediated clearance and Alzheimer's disease progression.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Diurnal choroid plexus function in mice depends on sex, age, and amyloid-β status.Communications biology · 2026Article
- Choroid plexus modulates subventricular zone adult neurogenesis and olfaction through secretion of small extracellular vesicles.Fluids and barriers of the CNS · 2026Article
- Morphological and Molecular Characteristics of Choroid Plexus Epithelium in Aged Brains.International journal of molecular sciences · 2026Review
- Surrogates of glymphatic metrics decline and coupled sleep rhythms disruption in Alzheimer's disease.Alzheimer's research & therapy · 2026Article
- Association of choroid plexus volume with brain atrophy and glucose metabolism in multiple system atrophy.Scientific reports · 2026Article
- Cross-sectional investigation of choroid plexus calcification, cardiovascular risk score, and APOEε4 Status in cognitively normal cohort.Cerebral circulation - cognition and behavior · 2026Article
- The choroid plexus water density.Magnetic resonance in medicine · 2026Article
26 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors at 1 institution in 2 countries.
Funding
Abstract
The choroid plexus (ChP) is a major source of cerebrospinal fluid (CSF) production, with a direct and indirect role in protein clearance, and pathogenesis of Alzheimer's disease (AD). Here, we tested the link between the ChP volume and levels of CSF proteins in 2 data sets of (i) healthy controls, mild cognitive impairment (MCI), and AD patients from the Alzheimer's Disease Neuroimaging Initiative (ADNI) (N = 509), and (ii) healthy controls and Parkinson's disease (PD) patients from the Parkinson's Progression Markers Initiative (N = 302). All patients had baseline CSF proteins (amyloid-β, total and phosphorylated-tau and α-synuclein (only in Parkinson's Progression Markers Initiative)). ChP was automatically segmented on 3T structural T1-weighted MRIs. We found negative associations between ChP volume and CSF proteins, which were stronger in healthy controls, early-MCI patients, and PD patients compared with late-MCI and AD patients. Further grouping of patients of ADNI dataset into amyloid-positive and amyloid-negative based on their florbetapir (AV45) PET imaging showed that the association between ChP volume and CSF proteins (t/p-tau) was lower in amyloid-positive group. Our findings support the possible role of ChP in the clearance of CSF proteins, provide evidence for ChP dysfunction in AD, and suggest the need to account for the ChP volume in future studies of CSF-based biomarkers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.