Evidence map›Paper›PMID 32107005›Full record

ArticleBiological psychiatry2020

Cholinergic Modulation of Disorder-Relevant Neural Circuits in Generalized Anxiety Disorder.

Toby Wise, Fiona Patrick, Nicholas Meyer, Ndaba Mazibuko, Alice E Oates, Anne H M van der Bijl, Philippe Danjou, Susan M O'Connor, Elizabeth Doolin, Caroline Wooldridge and 5 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biological psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Review
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 4 countries.

Toby WiseDepartment of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK; Wellcome Trust Centre for Neuroimaging, University College London, London, UK; Max Planck UCL Centre for Computational Psychiatry and Ageing Research, London, UK; Department of Humanities and Social Sciences, California Institute of Technology, Pasadena, California. Electronic address: t.wise@ucl.ac.uk.
Fiona PatrickDepartment of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK; Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Nicholas MeyerDepartment of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Ndaba MazibukoDepartment of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Alice E OatesMaudsley NHS Foundation Trust, London, UK.
Anne H M van der BijlFaculty of Social and Behavioural Sciences, University of Leiden, Leiden, Netherlands.
Philippe DanjouBiotrial, Paris, France.
Susan M O'ConnorBionomics Ltd, Thebarton, Australia.
Elizabeth DoolinBionomics Ltd, Thebarton, Australia.
Caroline WooldridgeDepartment of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Deborah RathjenBiOasis Technologies Inc., Guilford, Connecticut.
Christine MacareDepartment of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Steven C R WilliamsDepartment of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK; National Institute for Health Research Biomedical Research Centre, South London, London, UK.
Adam PerkinsDepartment of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK; National Institute for Health Research Biomedical Research Centre, South London, London, UK.
Allan H YoungDepartment of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK; National Institute for Health Research Biomedical Research Centre, South London, London, UK.
King's College London · GBBionomics (Australia) · AUCalifornia Institute of Technology · USLeiden University · NLSouth London and Maudsley NHS Foundation Trust · GB

Funding

Medical Research Council MR/P001378/1Wellcome Trust 206460/Z/17/Z
6 · The paper itself

Abstract

backgroundGeneralized anxiety disorder is associated with hyperactivity in the amygdala-prefrontal networks, and normalization of this aberrant function is thought to be critical for successful treatment. Preclinical evidence implicates cholinergic neurotransmission in the function of these systems and suggests that cholinergic modulation may have anxiolytic effects. However, the effects of cholinergic modulators on the function of anxiety-related networks in humans have not been investigated.

methodsWe administered a novel α7 nicotinic acetylcholine receptor-negative allosteric modulator, BNC210, to 24 individuals (3 male subjects) with generalized anxiety disorder and assessed its effects on neural responses to fearful face stimuli.

resultsBNC210 reduced amygdala reactivity to fearful faces relative to placebo and similarly to lorazepam and also reduced connectivity between the amygdala and the anterior cingulate cortex, a network involved in regulating anxious responses to aversive stimuli.

conclusionsThese results demonstrate for the first time that the function of disorder-relevant neural circuits in generalized anxiety disorder can be beneficially altered through modulation of cholinergic neurotransmission and suggest potential for this system as a novel target for anxiolytic pharmacotherapy.

Indexed as

Anxiety DisordersMagnetic Resonance ImagingAmygdalaCholinergic AgentsFacial ExpressionFearHumansMalePrefrontal CortexCholinergic AgentsAmygdalaAnterior cingulate cortexCholinergic modulationfMRIGeneralized anxiety disorderPharmacotherapy

Identifiers

PMID32107005
PMCPMC7198974
OpenAlexW2999075249

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.