Evidence map›Paper›PMID 32106972›Full record

ReviewFertility and sterility2020

Frozen-thawed embryo transfer: the potential importance of the corpus luteum in preventing obstetrical complications.

Bhuchitra Singh, Lauren Reschke, James Segars, Valerie L Baker

Registry-linked trialOpen access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Fertility and sterility, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05215119 (Comparison of Immediate With Delayed Natural Cycle Frozen Embryo Transfers From Freeze-all-IVF Cycles), which is not on this map. Cited by 100 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
100citing papers in PubMed, 8 pooled it
38.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05215119 completednot on this mapstarted 2022, after this paper: background citation

Comparison of Immediate With Delayed Natural Cycle Frozen Embryo Transfers From Freeze-all-IVF Cycles: a Randomized Control Trial of First Frozen Embryo Transfers

TypeobservationalSponsorAntalya IVFRan2022 to 2025Enrolled818ConditionsClinical PregnancyArmsnatural cycle endometrial preparation
3 · Its place in the literature

Who cites it

100 citing papers in PubMed, 8 syntheses or guidelines pooled it, 187 citations in OpenAlex.

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  8. Fresh versus frozen embryo transfers in assisted reproduction.The Cochrane database of systematic reviews · 2021
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40 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Bhuchitra SinghDivision of Reproductive Sciences and Women's Health Research, Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Lutherville, Maryland.
Lauren ReschkeDivision of Reproductive Endocrinology and Infertility, Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Lutherville, Maryland.
James SegarsDivision of Reproductive Sciences and Women's Health Research, Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Lutherville, Maryland.
Valerie L BakerDivision of Reproductive Endocrinology and Infertility, Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Lutherville, Maryland. Electronic address: valbaker@jhmi.edu.
Johns Hopkins Medicine · USJohns Hopkins University · US

Funding

1/3 A randomized controlled trial of frozen embryo transfers performed in modified natural versus programmed cycles (NatPro)R01HD100341 · NICHD · JOHNS HOPKINS UNIVERSITY · PI BAKER, VALERIE LYNN, SEGARS, JAMES H. · 2019 to 2023
$9.3M
NICHD NIH HHS R01 HD100341
6 · The paper itself

Abstract

The use of frozen-thawed embryo transfer (FET) has increased over the past decade with improvements in technology and increasing live birth rates. FET facilitates elective single-embryo transfer, reduces ovarian hyperstimulation syndrome, optimizes endometrial receptivity, allows time for preimplantation genetics testing, and facilitates fertility preservation. FET cycles have been associated, however, with an increased risk of hypertensive disorders of pregnancy for reasons that are not clear. Recent evidence suggests that absence of the corpus luteum (CL) could be at least partly responsible for this increased risk. In a recent prospective cohort study, programmed FET cycles (no CL) were associated with higher rates of preeclampsia and preeclampsia with severe features compared with modified natural FET cycles. FET cycles are commonly performed in the context of a programmed cycle in which the endometrium is prepared with the use of exogenous E

Indexed as

Adaptation, PhysiologicalCorpus LuteumCryopreservationEmbryo TransferFemaleHumansInfant, Low Birth WeightPlacenta PreviaPre-EclampsiaPregnancyPregnancy OutcomeFrozen embryo transfernatural cyclepreeclampsiapregnancy outcomesprogrammed cycle

Identifiers

PMID32106972
PMCPMC7380557
OpenAlexW3006907233

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.