ArticleBMC pregnancy and childbirth2020
Elevated C-reactive protein and complement C3 levels are associated with preterm birth: a nested case-control study in Chinese women.
Article in BMC pregnancy and childbirth, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Is there a maternal blood biomarker that can predict spontaneous preterm birth prior to labour onset? A systematic review.PloS one · 2022Pooled it
- Association Between Maternal C-Reactive Protein (CRP) Levels and Adverse Neonatal Outcomes: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2026Review
- Relationship between the dietary inflammatory index and immune function during pregnancy - A secondary analysis of the MicrobeMom2 Study.European journal of clinical nutrition · 2026Article
- Comparative machine learning models for early prediction of preterm birth from maternal serum biomarkers.BMC pregnancy and childbirth · 2026Article
- Comparison of Interpretable Machine Learning Models Using Systemic Inflammation Index to Predict Preterm Birth in Gestational Diabetes Mellitus.International journal of women's health · 2026Article
- Early pregnancy maternal lipid profile, acute phase responders, and the association with preterm delivery and selected pregnancy outcomes.Pregnancy (Hoboken, N.J.) · 2025Article
- The Predictive Role of Maternal Serum Amyloid A in Preterm Birth: An Observational Study in Romania.Cureus · 2024Article
- Iron status, anemia, and birth outcomes among pregnant women in urban Bloemfontein, South Africa: the NuEMI study.BMC pregnancy and childbirth · 2024Article
- Is the central complement component C3 altered in the synergy of HIV infection and preeclampsia?European journal of obstetrics & gynecology and reproductive biology: X · 2023Article
- Article
- C-Reactive Protein: Pathophysiology, Diagnosis, False Test Results and a Novel Diagnostic Algorithm for Clinicians.Diseases (Basel, Switzerland) · 2023Review
- The complement system in preeclampsia: a review of its activation and endothelial injury in the triad of COVID-19 infection and HIV-associated preeclampsia.Obstetrics & gynecology science · 2023Article
- Development and validation of nomogram for the prediction of preterm delivery based on patient characteristics and circulating inflammatory cells in patients with gestational diabetes mellitus.Annals of translational medicine · 2023Article
- Identification of potential therapeutic intervening targets by in-silico analysis of nsSNPs in preterm birth-related genes.PloS one · 2023Article
- Complement regulation in ovine lymph nodes during early pregnancy.Experimental and therapeutic medicine · 2022Article
- The landscape of circular RNA in preterm birth.Frontiers in immunology · 2022Article
- Article
- Association of Complement-Related Proteins in Subjects With and Without Second Trimester Gestational Diabetes.Frontiers in endocrinology · 2021Article
- Cytokine Patterns in Maternal Serum From First Trimester to Term and Beyond.Frontiers in immunology · 2021Article
- SARS-CoV-2 in Pregnant Women: Consequences of Vertical Transmission.Frontiers in cellular and infection microbiology · 2021Article
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCurrently, there are many studies researched the associations between maternal serum inflammatory indicators (i.e. ferritin, C-reactive protein [CRP], C3 and C4) and preterm birth (PTB). The results, however, are inconsistent. Therefore, the aim of this study was to estimate the relationship between maternal serum inflammatory indicators and PTB in a nested case-control (NCC)study.
methodsA NCC study was conducted by Guangxi Birth Cohort Study which enrolled a total of 6203 pregnant women between 5
resultsHighest quartile concentrations of all inflammatory indicators were determined versus median. After adjusting for maternal age, high levels of CRP (CRP > 16.60 mg/L) are related to the risk of PTB (OR = 2.16, 95% CI: 1.02-4.56, p = 0.044) in the first trimester. The association of C3 was extremely related to those who delivered PTB (OR = 2.53, 95% CI: 1.14-5.64, p = 0.023) in the first trimester. Moreover, no significant associations were found in C4 (p = 0.079) and ferritin (p = 0.067) between PTB.
conclusionsElevated concentrations of CRP and C3 in the first trimester were associated with increased risk of PTB. Inflammatory indicators may act a pivotal part in early diagnosis and prognosis of PTB.
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