ArticleBMC infectious diseases2020
The cause of death in bacterial meningitis.
Article in BMC infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 4 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- The role of fluid restriction in acute bacterial meningitis: A systematic review.BMC medicine · 2026Pooled it
- Longer than 2 hours to antibiotics is associated with doubling of mortality in a multinational community-acquired bacterial meningitis cohort.Scientific reports · 2022Pooled it
- Non-corticosteroid adjuvant therapies for acute bacterial meningitis.The Cochrane database of systematic reviews · 2021Pooled it
- Post-Traumatic Meningitis Is a Diagnostic Challenging Time: A Systematic Review Focusing on Clinical and Pathological Features.International journal of molecular sciences · 2020Pooled it
- Bioengineered Extracellular Vesicles Mitigate Neuroinflammation by Neutralizing Pneumolysin and Delaying Disease Onset in Experimental Pneumococcal Meningitis.Journal of extracellular vesicles · 2026Article
- Lumbar Puncture and Brain Herniation in Acute Bacterial Meningitis: An Updated Narrative Review.Journal of intensive care medicine · 2026Review
- Diagnostic Accuracy of Cerebrospinal Fluid Presepsin vs. Procalcitonin in Post-Neurosurgical Bacterial Ventriculitis/Meningitis: A Machine Learning Analytical Approach.Journal of molecular neuroscience : MN · 2026Article
- Estimating the impact of decreasing vaccination response times for outbreaks of vaccine-preventable diseases in low- and middle-income countries.BMC global and public health · 2026Article
- A case report and literature review of neuropsychiatric lupus presenting with coma as the initial symptom.Medicine · 2026Review
- Middle ear secretions following spontaneous CSF leak repair may represent effusion rather than CSF leak.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025Article
- The Current Situation of Neurological Health in Bangladesh: A Perspective.Health science reports · 2025Article
- Intracranial complications in adult patients with severe pneumococcal meningitis: a retrospective multicenter cohort study.Annals of intensive care · 2024Article
- Post-Meningitic Syndrome: Pathophysiology and Consequences of Streptococcal Infections on the Central Nervous System.International journal of molecular sciences · 2024Review
- Intracranial pressure monitoring in the management of acute bacterial meningitis: controversy or clinical practice?Acta neurochirurgica · 2024Article
- Cerebrospinal fluid cytokines and chemokines exhibit distinct profiles in bacterial meningitis and viral meningitis.Experimental and therapeutic medicine · 2023Article
- [The new 15-valent pneumococcal conjugate vaccine for the prevention ofJournal of preventive medicine and hygiene · 2023Article
- Bacterial meningitis in children with an abnormal craniocerebral structure.Frontiers in pediatrics · 2023Article
- Memory Impairment, Pro-Inflammatory Host Response and Brain Histopathologic Severity in Rats Infected withPathogens (Basel, Switzerland) · 2022Article
- The Cost of Suspected and Confirmed Bacterial Meningitis Cases Treated at Jimma University Medical Center, Ethiopia.Ethiopian journal of health sciences · 2022Article
- Neutrophil lymphocyte ratio as predictor of mortality in pediatric patients with bacterial meningitis: A retrospective cohort study.Annals of medicine and surgery (2012) · 2022Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundDeath from bacterial meningitis is rarely attributed to the actual event causing death. The present study therefore categorized and characterized the cause and time of death due to bacterial meningitis.
methodsIn a cohort of patients > 15 years of age with community acquired bacterial meningitis the medical records were reviewed, and a clinical cause of death categorized into six main categories: 1) CNS complications, 2) Systemic complications, 3) Combination of systemic and CNS complications, 4) Sudden death, 5) Withdrawal of care, or 6) Unknown.
resultsWe identified 358 patients of which 84 (23%) died in-hospital. Causes of death were ascribed to CNS complications in 43%, Systemic complications in 39%, Combined CNS and systemic complications in 4%, Sudden death in 7% and withdrawal of care in 5%. Brain herniation, circulatory failure, intractable seizures and other brain injury were the most common specific causes of death within 14 days from admission (55%).
conclusionFatal complications due to the primary infection - meningitis - is most common within 14 days of admission. The diversity of complications causing death in meningitis suggest that determining the clinical cause of death is essential to the evaluation of novel treatment strategies.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.