Evidence map›Paper›PMID 32106789›Full record

ArticleLupus2020

Elevated IgA antiphospholipid antibodies in healthy pregnant women in Sudan but not Sweden, without corresponding increase in IgA anti-β

S Elbagir, N A Mohammed, H Kaihola, E Svenungsson, I Gunnarsson, V A Manivel, E Pertsinidou, E M Elagib, M A M Nur, E A Elussein and 3 more

Open access · hybridAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Lupus, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
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  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

S ElbagirDepartment of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.ORCID https://orcid.org/0000-0003-2515-7066
N A MohammedFaculty of Medical Laboratory Sciences, Al Neelain University, Khartoum, Sudan.
H KaiholaDepartment of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
E SvenungssonDivision of Rheumatology, Department of Medicine, Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
I GunnarssonDivision of Rheumatology, Department of Medicine, Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
V A ManivelDepartment of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
E PertsinidouDepartment of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
E M ElagibRheumatology Unit, Military Hospital, Omdurman, Sudan.
M A M NurRheumatology Unit, Alribat University Hospital, Khartoum, Sudan.
E A ElusseinKhartoum Fertility Center, Academy of Medical Sciences and Technology, Khartoum, Sudan.
A ElshafieDepartment of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
H ÅkerudDepartment of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
J RönnelidDepartment of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
Uppsala University · SEKarolinska University Hospital · SEAl-Neelain University · SDUniversity of Medical Sciences and Technology · SD

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe role of antiphospholipid antibodies (aPL) during apparently normal pregnancy is still unclear. IgA aPL are prevalent in populations of African origin. Our aim was to measure all isotypes of anticardiolipin (anti-CL) and anti-β

methodsHealthy Sudanese pregnant women (

resultsPregnant Sudanese women had significantly higher median levels of IgA anti-CL, IgA anti-β

conclusionsIgA aPL are increased in Sudanese but not in Swedish women, without corresponding increase in IgA domain 1. Whether due to ethnicity and/or environmental influences the occurrence of IgA aPL during Sudanese pregnancies, and its clinical significance, is yet to be determined.

Indexed as

AdultAntibodies, AnticardiolipinAntibodies, AntiphospholipidAntiphospholipid Syndromebeta 2-Glycoprotein IFemaleHumansImmunoglobulin APregnancyPregnancy ComplicationsRheumatoid FactorSudanSwedenYoung AdultAntibodies, AnticardiolipinAntibodies, Antiphospholipidbeta 2-Glycoprotein IImmunoglobulin ARheumatoid FactorAfricaAntiphospholipid antibodieshealthyIgApregnancySudan

Identifiers

PMID32106789
PMCPMC7488825
OpenAlexW3007806825

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.