Evidence map›Paper›PMID 32106607›Full record

ReviewMolecules (Basel, Switzerland)2020

Small Dimension-Big Impact! Nanoparticle-Enhanced Non-Invasive and Intravascular Molecular Imaging of Atherosclerosis In Vivo.

Tobias Lenz, Philipp Nicol, Maria Isabel Castellanos, Leif-Christopher Engel, Anna Lena Lahmann, Christoph Alexiou, Michael Joner

Open access · goldAbstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. PET imaging of atherosclerotic plaques using the stabilin-2-targeted tracerEuropean journal of nuclear medicine and molecular imaging · 2026
    Article
  2. Review
  3. Article
  4. Unveiling the role of ABI3 and hub senescence-related genes in macrophage senescence for atherosclerotic plaque progression.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2024
    Article
  5. Review
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Tobias LenzGerman Heart Centre Munich, Technical University of Munich, Lazarettstraße 36, 80636 Munich, Germany.
Philipp NicolGerman Heart Centre Munich, Technical University of Munich, Lazarettstraße 36, 80636 Munich, Germany.
Maria Isabel CastellanosGerman Heart Centre Munich, Technical University of Munich, Lazarettstraße 36, 80636 Munich, Germany.
Leif-Christopher EngelGerman Heart Centre Munich, Technical University of Munich, Lazarettstraße 36, 80636 Munich, Germany.
Anna Lena LahmannGerman Heart Centre Munich, Technical University of Munich, Lazarettstraße 36, 80636 Munich, Germany.
Christoph AlexiouDepartment of Oto-Rhino-Laryngology, Head and Neck Surgery, Section of Experimental Oncology and Nanomedicine (SEON), Else Kröner-Fresenius-Stiftung-Professorship, University Hospital Erlangen, 91054 Erlangen, Germany.
Michael JonerGerman Heart Centre Munich, Technical University of Munich, Lazarettstraße 36, 80636 Munich, Germany.
Deutsches Herzzentrum München · DETechnical University of Munich · DEUniversitätsklinikum Erlangen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extensive translational research has provided considerable progress regarding the understanding of atherosclerosis pathophysiology over the last decades. In contrast, implementation of molecular in vivo imaging remains highly limited. In that context, nanoparticles represent a useful tool. Their variable shape and composition assure biocompatibility and stability within the environment of intended use, while the possibility of conjugating different ligands as well as contrast dyes enable targeting of moieties of interest on a molecular level and visualization throughout various imaging modalities. These characteristics have been exploited by a number of preclinical research approaches aimed at advancing understanding of vascular atherosclerotic disease, in order to improve identification of high-risk lesions prior to oftentimes fatal thromboembolic events. Furthermore, the combination of these targeted nanoparticles with therapeutic agents offers the potential of site-targeted drug delivery with minimized systemic secondary effects. This review gives an overview of different groups of targeted nanoparticles, designed for in vivo molecular imaging of atherosclerosis as well as an outlook on potential combined diagnostic and therapeutic applications.

Indexed as

AtherosclerosisBlood VesselsContrast MediaHumansMolecular ImagingNanoparticlesPlaque, AtheroscleroticContrast Mediaatherosclerosismolecular imagingnanoparticles

Identifiers

PMID32106607
PMCPMC7179220
OpenAlexW3007315132

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.