Evidence map›Paper›PMID 32106462›Full record

ArticleMicromachines2020

Disposable DNA Amplification Chips with Integrated Low-Cost Heaters.

Henk-Willem Veltkamp, Fernanda Akegawa Monteiro, Remco Sanders, Remco Wiegerink, Joost Lötters

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Micromachines, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Henk-Willem VeltkampDepartment of Integrated Devices and Systems, University of Twente, PO Box 217, 7500 AE Enschede, The Netherlands.
Fernanda Akegawa MonteiroDepartment of Integrated Devices and Systems, University of Twente, PO Box 217, 7500 AE Enschede, The Netherlands.
Remco SandersDepartment of Integrated Devices and Systems, University of Twente, PO Box 217, 7500 AE Enschede, The Netherlands.
Remco WiegerinkDepartment of Integrated Devices and Systems, University of Twente, PO Box 217, 7500 AE Enschede, The Netherlands.ORCID 0000-0001-5571-739X
Joost LöttersDepartment of Integrated Devices and Systems, University of Twente, PO Box 217, 7500 AE Enschede, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fast point-of-use detection of, for example, early-stage zoonoses, e.g., Q-fever, bovine tuberculosis, or the Covid-19 coronavirus, is beneficial for both humans and animal husbandry as it can save lives and livestock. The latter prevents farmers from going bankrupt after a zoonoses outbreak. This paper describes the development of a fabrication process and the proof-of-principle of a disposable DNA amplification chip with an integrated heater. Based on the analysis of the milling process, metal adhesion studies, and COMSOL MultiPhysics heat transfer simulations, the first batch of chips has been fabricated and successful multiple displacement amplification reactions are performed inside these chips. This research is the first step towards the development of an early-stage zoonoses detection device. Tests with real zoonoses and DNA specific amplification reactions still need to be done.

Indexed as

cyclic olefin copolymerearly-stage disease detectionintegrated heatersmultiple displacement amplificationon-chip DNA amplificationpolymer-based disposable microfluidic chipszoonoses

Identifiers

PMID32106462
PMCPMC7143804

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.