Evidence map›Paper›PMID 32106359›Full record

ArticleBrain and behavior2020

Ionizing radiation modulates vascular endothelial growth factor expression through STAT3 signaling pathway in rat neonatal primary astrocyte cultures.

Guijuan Zhou, Yan Xu, Bing He, Rundong Ma, Yilin Wang, Yunqian Chang, Yangzhi Xie, Lin Wu, Jianghua Huang, Zijian Xiao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain and behavior, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Guijuan ZhouThe First Afliated Hospital of University of South China, University of South China, Hengyang, China.
Yan XuThe First Afliated Hospital of University of South China, University of South China, Hengyang, China.
Bing HeThe First Afliated Hospital of University of South China, University of South China, Hengyang, China.
Rundong MaThe First Afliated Hospital of University of South China, University of South China, Hengyang, China.
Yilin WangThe First Afliated Hospital of University of South China, University of South China, Hengyang, China.
Yunqian ChangThe First Afliated Hospital of University of South China, University of South China, Hengyang, China.
Yangzhi XieThe First Afliated Hospital of University of South China, University of South China, Hengyang, China.
Lin WuThe First Afliated Hospital of University of South China, University of South China, Hengyang, China.
Jianghua HuangThe First Afliated Hospital of University of South China, University of South China, Hengyang, China.
Zijian XiaoThe First Afliated Hospital of University of South China, University of South China, Hengyang, China.ORCID 0000-0001-5137-9549
First Affiliated Hospital of University of South China · CN

Funding

Foundation of Health and Family planning Commission of Hunan Province C20180143Hengyang Science and Technology Development Foundation 2016KJ38Hunan Provincial Innovation Foundation For Postgraduate 20190769Natural Science Foundation of Hunan Province 2017JJ3273
6 · The paper itself

Abstract

background and purposeRadiation-induced brain injury (RBI) usually occurs six months to three years after irradiation, often shows cognitive dysfunction, epilepsy, and other neurological dysfunction. In severe cases, it can cause a wide range of cerebral edema, even herniation. It seriously threatens the survival of patients and their quality of life, and it becomes a key factor in limiting the radiation dose and lowering the therapeutic efficacy in recent years. Therefore, studying the pathogenesis of RBI and exploring new therapeutic targets are of great significance.

methodsIn our study, we observed the activation and secretory function in astrocytes as well as the intracellular signal transducer and activator of transcription 3 (STAT3) signal transduction pathway activation status after exposing different doses of X-ray irradiation by using MTT, Immunocytologic analysis, and Western blot analysis. Further, we used the same way to explore the role of vascular endothelial growth factor (VEGF) in signal transduction pathways playing in the activation of astrocytes after irradiating through the use of specificInhivascular endothelial growth factorbitors of STAT3.

resultsAst can be directly activated, reactive hyperplasia and hypertrophy, the expression of the activation marker glial fibrillary acidic protein is increased, and the expression of vascular endothelial growth factor (VEGF) in the cells is increased, which may lead to RBI. After the addition of STAT3 pathway inhibitor, most of the Ast radiation activation was suppressed, and the expression of high-level expression of VEGF decreased after irradiation.

conclusionOur findings demonstrated that X-ray irradiation directly induced the activation of astrocytes in a persistent manner and X-ray irradiation activated STAT3 signaling pathway. As the same time, we found that X-ray irradiation induced the activation of astrocytes and secretion cytokine. The STAT3 signaling pathway may participate in the pathogenesis of radiation-induced brain injury.

Indexed as

Radiation, IonizingAnimalsAstrocytesCerebral CortexGlial Fibrillary Acidic ProteinRatsRats, Sprague-DawleySignal TransductionSTAT3 Transcription FactorVascular Endothelial Growth Factor AGlial Fibrillary Acidic ProteinSTAT3 Transcription FactorVascular Endothelial Growth Factor Aastrocytesglial fibrillary acidic proteinradiation-induced brain injurysignal transducer and activator of transcription 3vascular endothelial growth factor

Identifiers

PMID32106359
PMCPMC7177558
OpenAlexW3007675747

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.