ArticleNature2020
Mutational signature in colorectal cancer caused by genotoxic pks
Open access · greenAbstract read
In one paragraph
Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 751 papers, 4 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
751citing papers in PubMed, 4 pooled it
48.8field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
751 citing papers in PubMed, 4 syntheses or guidelines pooled it, 1,086 citations in OpenAlex.
- Fecal Microbiome Alterations in Colorectal Cancer: A Systematic Review of Compositional Changes and Microbial Biomarkers.MicrobiologyOpen · 2026Pooled it
- The Hidden Link Between Intestinal Helminthiasis, Gut Microbiome Alterations, and Colorectal Cancer Risk: A Systematic Review.International journal of molecular sciences · 2026Pooled it
- IBD-related inflammatory memory and colorectal cancer: epigenetic mechanisms and microbiome interventions.Frontiers in immunology · 2026Pooled it
- [Fecal Microbiota Transplantation: A Promising Avenue for Lung Cancer Therapy].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2025Pooled it
- Full-length 16S rRNA nanopore sequencing enables species resolution ofGut microbes · 2026Article
- Article
- Altered crosstalk of bacterial lipopolysaccharide with immune cells in colorectal cancer compared to paired adjacent intestinal tissue.Gut microbes · 2026Article
- Recent advances and clinical relevance of microbiome dynamics in health and disease.Gut microbes · 2026Review
- Dysregulated eating behaviour and microbiota-based interventions targeting eating disorders and food addiction.Gut microbes · 2026Review
- Gut microbiota and diet in colorectal cancer: Converging determinants of carcinogenesis.Gut microbes · 2026Review
- Temporal dynamics of gut biosynthetic gene clusters link persistent colonization and engraftment in fecal microbiota transplantation.Gut microbes · 2026Article
- Review
- Modulating the gut microbiota to enhance immune checkpoint inhibitor efficacy in colorectal cancer: mechanisms, therapeutic strategies, and clinical perspectives.Gut microbes · 2026Review
- Incidence Trends of Early-Onset Colorectal Cancer in Germany: A Registry-Based Study From 2003 to 2023.International journal of cancer · 2026Article
- Rising Incidence and Mortality of Colorectal Cancer Among Younger Adults: A Population-Based Study in Taiwan, 1994-2018.International journal of cancer · 2026Article
- Nitric Oxide in the Intestinal Stem Cell Niche: A Spatial Model of Nitrosative Stress and Clonal Evolution in Colitis-Associated Colorectal Cancer.Digestive diseases and sciences · 2026Review
- Shaping the future of early-onset colorectal cancer prevention.Nature reviews. Cancer · 2026Review
- Tutorial: interrogating biology using organoid technologies.Nature protocols · 2026Review
- Colibactin produced by a honeybee gut symbiont mediates pathogen defence.Nature microbiology · 2026Article
- Intratumoral microbiota in colorectal cancer: roles, therapeutic potential, and challenges.Journal of advanced research · 2026Review
691 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
28 authors at 9 institutions in 4 countries.
Cayetano Pleguezuelos-Manzano *Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and UMC Utrecht, Utrecht, The Netherlands.
Jens Puschhof *Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and UMC Utrecht, Utrecht, The Netherlands.
Axel Rosendahl Huber *Oncode Institute, Utrecht, The Netherlands.
Arne van HoeckOncode Institute, Utrecht, The Netherlands.ORCID http://orcid.org/0000-0002-6570-1452
Henry M WoodPathology and Data Analytics, Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, UK.ORCID http://orcid.org/0000-0003-3009-5904
Jason NomburgGraduate Program in Virology, Division of Medical Sciences, Harvard Medical School, Boston, MA, USA.
Carino GurjaoDepartment of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA.
Freek MandersOncode Institute, Utrecht, The Netherlands.ORCID http://orcid.org/0000-0001-6197-347X
Guillaume DalmassoUniversity Clermont Auvergne, Inserm U1071, INRA USC2018, M2iSH, Clermont-Ferrand, France.ORCID http://orcid.org/0000-0002-3433-870X
Paul B StegeDepartment of Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands.
Fernanda L PaganelliDepartment of Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands.
Maarten H GeurtsHubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and UMC Utrecht, Utrecht, The Netherlands.
Joep BeumerHubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and UMC Utrecht, Utrecht, The Netherlands.
Tomohiro MizutaniHubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and UMC Utrecht, Utrecht, The Netherlands.ORCID http://orcid.org/0000-0002-8373-7969
Yi MiaoHoward Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA, USA.
Reinier van der LindenHubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and UMC Utrecht, Utrecht, The Netherlands.ORCID http://orcid.org/0000-0001-7437-8901
Stefan van der ElstHubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and UMC Utrecht, Utrecht, The Netherlands.
Genomics England Research Consortium
K Christopher GarciaHoward Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA, USA.
Janetta TopDepartment of Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands.
Rob J L WillemsDepartment of Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands.
Marios GiannakisDepartment of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA.
Richard BonnetUniversity Clermont Auvergne, Inserm U1071, INRA USC2018, M2iSH, Clermont-Ferrand, France.
Phil QuirkePathology and Data Analytics, Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, UK.ORCID http://orcid.org/0000-0002-3597-5444
Matthew MeyersonDepartment of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-9133-8108
Edwin CuppenOncode Institute, Utrecht, The Netherlands.
Ruben van BoxtelOncode Institute, Utrecht, The Netherlands. R.vanBoxtel@prinsesmaximacentrum.nl.ORCID http://orcid.org/0000-0003-1285-2836
Hans CleversHubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and UMC Utrecht, Utrecht, The Netherlands. h.clevers@hubrecht.eu.ORCID http://orcid.org/0000-0002-3077-5582
Genomics England · GBQueen Mary University of London · GBRoyal Netherlands Academy of Arts and Sciences · NLUniversity Medical Center Utrecht · NLBroad Institute · USOncode Institute · NLHoward Hughes Medical Institute · USInserm · FRUniversity of Leeds · GB
Funding
Structure-based Bioengineering of Wnt Surrogates for Intestinal Stem Cell Biology and TherapyR01DK115728 · NIDDK · STANFORD UNIVERSITY · PI GARCIA, KENAN CHRISTOPHER, KUO, CALVIN J · 2018 to 2022
$3.9MWnt Proteins During Intestinal Repair and RegenerationR01DK069989 · NIDDK · STANFORD UNIVERSITY · PI KUO, CALVIN J · 2005 to 2009
$1.5MCancer Research UK 27140Howard Hughes Medical InstituteMedical Research Council MC_EX_MR/M009203/1Medical Research Council MC_PC_14089Medical Research Council MR/M009203/1NIDDK NIH HHS R01 DK069989NIDDK NIH HHS R01 DK115728NIH HHS 1R01DK115728-01A1Wellcome Trust
Abstract
Various species of the intestinal microbiota have been associated with the development of colorectal cancer
Indexed as
MutagenesisMutationCoculture TechniquesCohort StudiesColorectal NeoplasmsConsensus SequenceDNA DamageEscherichia coliGastrointestinal MicrobiomeGenomic IslandsHumansOrganoidsPeptidesPolyketidescolibactinPeptidesPolyketides
Identifiers
What OpenQuestion holds
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.