ArticleResearch in developmental disabilities2020
A preliminary examination of brain morphometry in youth with Down syndrome with and without parent-reported sleep difficulties.
Article in Research in developmental disabilities, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 7 citations in OpenAlex.
- Sleep Bruxism, Pharmacotherapy, Sleep Aspects and Screen Use in Children and Adolescents With Down Syndrome: A Cluster Analysis.Journal of applied research in intellectual disabilities : JARID · 2026Article
- Youth with Down syndrome display widespread increased functional connectivity during rest.Scientific reports · 2022Article
- Circadian Sleep-Activity Rhythm across Ages in Down Syndrome.Brain sciences · 2021Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundDown syndrome is associated with poor sleep but little is known about its neural correlates.
aimsThe current research compared brain morphometry in youth with Down syndrome with parent-reported sleep problems (DS-S) to peers with Down syndrome (DS) and typical development (TD) without parent-reported sleep problems matched on age (M = 15.15) and sex ratio (62 % female). METHODS AND PROCEDURES: Magnetic resonance imaging was completed on a 3 T scanner. Participants were stratified into groups based on parent-report: DS-S (n = 17), DS (n = 9), TD (n = 22). Brain morphometry, processed with the FreeSurfer Image Analysis Suite, was compared across groups. In addition, the co-occurrence of medical conditions in the DS groups was examined. OUTCOMES AND
resultsYouth with DS-S had reduced total, frontal, parietal, and temporal brain volumes relative to DS and TD peers. They also had higher rates of congenital heart defects than the DS-only group; however, this comorbidity did not appear to account for morphometry differences. CONCLUSIONS AND IMPLICATIONS: Parent-reported sleep problems in DS appear to relate to global and localized volume reductions. These preliminary results have implications for understanding the neural correlates of poor sleep in DS; they also highlight the importance of examining relations between sleep and other medical comorbidities.
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Registered trials
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