ArticlePsychiatry research. Neuroimaging2020
Neural correlates of symptom severity in obsessive-compulsive disorder using magnetization transfer and diffusion tensor imaging.
Article in Psychiatry research. Neuroimaging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 13 citations in OpenAlex.
- Neuroimaging and Machine Learning in OCD: Advances in Diagnostic and Therapeutic Insights.Brain sciences · 2025Review
- Changes in white matter microstructure in the brain of patients with inflammatory bowel disease are associated with abdominal pain.Frontiers in neuroscience · 2025Article
- Quantitative myelin imaging with MRI and PET: an overview of techniques and their validation status.Brain : a journal of neurology · 2023Review
- Individuals with problem gambling and obsessive-compulsive disorder learn through distinct reinforcement mechanisms.PLoS biology · 2023Article
- Application of advanced magnetic resonance imaging in glaucoma: a narrative review.Quantitative imaging in medicine and surgery · 2022Review
- Association between gray/white matter contrast and white matter microstructural alterations in medication-naïve obsessive-compulsive disorder.NeuroImage. Clinical · 2022Article
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 4 countries.
Funding
Abstract
Recent neuroimaging studies in OCD have reported structural alterations in the brain, not limited to frontostriatal regions. While Diffusion Tensor Imaging (DTI) is typically used to interrogate WM microstructure in OCD, additional imaging metric, such as Magnetization Transfer Imaging (MTI), allows for further identification of subtle but important structural changes across both GM and WM. In this study, both MTI and DTI were utilised to investigate the structural integrity of the brain, in OCD in relation to healthy controls. 38 adult OCD patients were recruited, along with 41 age- and gender-matched controls. Structural T1, MTI and DTI data were collected. Case-control differences in Magnetization Transfer Ratio (MTR) and DTI metrics (FA, MD) were examined, along with MTR/DTI-related associations with symptom severity in patients. No significant group differences were found across MTR, FA, and MD. However, OCD symptom severity was positively correlated with MTR in a distributed network of brain regions, including the striatum, cingulate, orbitofrontal area and insula. Within the same regions, OCD symptoms were also positively correlated with FA in WM, and negatively correlated with MD in GM. These results indicate a greater degree of myelination in certain cortical and subcortical regions in the more severe cases of OCD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.