Evidence map›Paper›PMID 32105967›Full record

ArticleEnvironmental pollution (Barking, Essex : 1987)2020

Prebiotic inulin consumption reduces dioxin-like PCB 126-mediated hepatotoxicity and gut dysbiosis in hyperlipidemic Ldlr deficient mice.

Jessie B Hoffman, Michael C Petriello, Andrew J Morris, M Abdul Mottaleb, Yipeng Sui, Changcheng Zhou, Pan Deng, Chunyan Wang, Bernhard Hennig

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental pollution (Barking, Essex : 1987), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 27 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
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  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Jessie B HoffmanSuperfund Research Center, University of Kentucky, Lexington, KY, USA; Department of Pharmacology and Nutritional Sciences, College of Medicine, University of Kentucky, USA.
Michael C PetrielloSuperfund Research Center, University of Kentucky, Lexington, KY, USA; Division of Cardiovascular Medicine, College of Medicine, University of Kentucky, Lexington, KY, USA; Lexington Veterans Affairs Medical Center, Lexington, KY, USA.
Andrew J MorrisSuperfund Research Center, University of Kentucky, Lexington, KY, USA; Division of Cardiovascular Medicine, College of Medicine, University of Kentucky, Lexington, KY, USA; Lexington Veterans Affairs Medical Center, Lexington, KY, USA.
M Abdul MottalebSuperfund Research Center, University of Kentucky, Lexington, KY, USA; Division of Cardiovascular Medicine, College of Medicine, University of Kentucky, Lexington, KY, USA; Lexington Veterans Affairs Medical Center, Lexington, KY, USA.
Yipeng SuiDepartment of Pharmacology and Nutritional Sciences, College of Medicine, University of Kentucky, USA.
Changcheng ZhouDepartment of Pharmacology and Nutritional Sciences, College of Medicine, University of Kentucky, USA.
Pan DengSuperfund Research Center, University of Kentucky, Lexington, KY, USA; Department of Animal and Food Sciences, College of Agriculture, Food and Environment, University of Kentucky, Lexington, KY, USA.
Chunyan WangSuperfund Research Center, University of Kentucky, Lexington, KY, USA; Department of Animal and Food Sciences, College of Agriculture, Food and Environment, University of Kentucky, Lexington, KY, USA.
Bernhard HennigSuperfund Research Center, University of Kentucky, Lexington, KY, USA; Department of Animal and Food Sciences, College of Agriculture, Food and Environment, University of Kentucky, Lexington, KY, USA. Electronic address: bhennig@uky.edu.
University of Kentucky · USLexington VA Health Care System · US

Funding

Vascular Mechanisms of PCB-Induced Brain MetastasesP42ES007380 · NIEHS · UNIVERSITY OF KENTUCKY · PI PENNELL, KELLY G · 1997 to 2024
$47.8M
Endocrine disruptor mediated activation of PXR causes dyslipidemia and atherosclerosisR01ES023470 · NIEHS · UNIVERSITY OF KENTUCKY · PI ZHOU, CHANGCHENG · 2013 to 2022
$2.7M
TRAINING PROGRAM IN OXIDATIVE STRESS AND NUTRITIONT32DK007778 · NIDDK · UNIVERSITY OF KENTUCKY · PI WEBB, NANCY R · 2000 to 2019
$2.5M
Role of IKKβ in obesity and atherosclerosisR01HL131925 · NHLBI · UNIVERSITY OF KENTUCKY · PI ZHOU, CHANGCHENG · 2016 to 2019
$1.5M
A novel mechanism for ART-associated dyslipidemia and atherosclerosisR01HL123358 · NHLBI · UNIVERSITY OF KENTUCKY · PI ZHOU, CHANGCHENG · 2015 to 2018
$1.5M
TMAO is a biomarker of dioxin-like pollutant exposure and cardiometabolic diseaseR00ES028734 · NIEHS · WAYNE STATE UNIVERSITY · PI PETRIELLO, MICHAEL CURTIS · 2019 to 2021
$747k
Triple Quadrupole Mass Spectrometer SystemS10OD021753 · OD · UNIVERSITY OF KENTUCKY · PI MORRIS, ANDREW J · 2017 to 2017
$352k
TMAO is a biomarker of dioxin-like pollutant exposure and cardiometabolic diseaseK99ES028734 · NIEHS · UNIVERSITY OF KENTUCKY · PI PETRIELLO, MICHAEL CURTIS · 2018 to 2018
$96k
NHLBI NIH HHS R01 HL123358NHLBI NIH HHS R01 HL131925NIDDK NIH HHS T32 DK007778NIEHS NIH HHS K99 ES028734NIEHS NIH HHS P42 ES007380NIEHS NIH HHS R00 ES028734NIEHS NIH HHS R01 ES023470NIH HHS S10 OD021753
6 · The paper itself

Abstract

Exposure to some environmental pollutants increases the risk of developing inflammatory disorders such as steatosis and cardiometabolic diseases. Diets high in fermentable fibers such as inulin can modulate the gut microbiota and lessen the severity of pro-inflammatory diseases, especially in individuals with elevated circulating cholesterol. Thus, we aimed to test the hypothesis that hyperlipidemic mice fed a diet enriched with 8% inulin would be protected from the pro-inflammatory toxic effects of PCB 126. Four groups of male Ldlr

Indexed as

Chemical and Drug Induced Liver InjuryDioxinsGastrointestinal MicrobiomeAnimalsDysbiosisInulinMaleMicePolychlorinated BiphenylsPrebioticsRNA, Ribosomal, 16S3,4,5,3',4'-pentachlorobiphenylDioxinsInulinPolychlorinated BiphenylsPrebioticsRNA, Ribosomal, 16SDioxinFiberGut microbiotaInulinPolychlorinated biphenyls

Identifiers

PMID32105967
PMCPMC7220843
OpenAlexW3008745297

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.