Evidence map›Paper›PMID 32105520›Full record

ReviewJournal of applied physiology (Bethesda, Md. : 1985)2020

CORP: Using transgenic mice to study skeletal muscle physiology.

C Brooks Mobley, Ivan J Vechetti, Taylor R Valentino, John J McCarthy

Open access · greenAbstract readReview
In one paragraph

Review in Journal of applied physiology (Bethesda, Md. : 1985), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Muscle-specific increased expression ofProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  5. Article
  6. Gene Manipulation of Muscle Phenotype.Advances in experimental medicine and biology · 2025
    Review
  7. Article
  8. Article
  9. CORP: Gene delivery into murine skeletal muscle using in vivo electroporation.Journal of applied physiology (Bethesda, Md. : 1985) · 2022
    Review
  10. Article
  11. Article
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

C Brooks MobleyDepartment of Physiology, College of Medicine, University of Kentucky, Lexington, Kentucky.ORCID 0000-0002-4045-9962
Ivan J VechettiDepartment of Physiology, College of Medicine, University of Kentucky, Lexington, Kentucky.
Taylor R ValentinoDepartment of Physiology, College of Medicine, University of Kentucky, Lexington, Kentucky.
John J McCarthyDepartment of Physiology, College of Medicine, University of Kentucky, Lexington, Kentucky.
University of Kentucky · US

Funding

The role of satellite cells in adult skeletal muscle growth and maintenanceR01AR060701 · NIAMS · UNIVERSITY OF KENTUCKY · PI MCCARTHY, JOHN JOSEPH, PETERSON, CHARLOTTE A. · 2010 to 2019
$3.3M
The effects of exercise on satellite cell dynamics during agingR01AG049806 · NIA · UNIVERSITY OF KENTUCKY · PI MCCARTHY, JOHN JOSEPH, PETERSON, CHARLOTTE A. · 2016 to 2020
$1.8M
NIAMS NIH HHS R01 AR060701NIA NIH HHS R01 AG049806
6 · The paper itself

Abstract

The development of tissue-specific inducible transgenic mice has provided a powerful tool to study gene function and cell biology in almost any tissue of interest at any given time within the animal's life. The purpose of this review is to describe how to use two different inducible transgenic systems, the Cre-loxP system and the Tet-ON/OFF system, that can be used to study skeletal muscle physiology. Myofiber- and satellite cell-specific Cre-loxP transgenic mice are described as is how these mice can be used to knockout a gene of interest or to deplete satellite cells in adult skeletal muscle, respectively. A myofiber-specific Tet-ON system is described as is how such mice can be used to overexpress a gene of interest or to label myonuclei. How to effectively breed and genotype the transgenic mice are also described in detail. The hope is this review will provide the basic information necessary to facilitate the incorporation of tissue-specific inducible transgenic mice into a skeletal muscle research program.

Indexed as

IntegrasesMusculoskeletal Physiological PhenomenaAnimalsMiceMice, KnockoutMice, TransgenicMuscle, SkeletalPhenotypeIntegrasesCre-loxPskeletal muscleTet-ON/OFFtransgenic mice

Identifiers

PMID32105520
PMCPMC7272760
OpenAlexW3008844357

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.