Evidence map›Paper›PMID 32105449›Full record

ArticleACS synthetic biology2020

Engineered Living Materials Based on Adhesin-Mediated Trapping of Programmable Cells.

Shuaiqi Guo, Emilien Dubuc, Yahav Rave, Mick Verhagen, Simone A E Twisk, Tim van der Hek, Guido J M Oerlemans, Maxime C M van den Oetelaar, Laura S van Hazendonk, Mariska Brüls and 13 more

Open access · hybridAbstract read
In one paragraph

Article in ACS synthetic biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 61 citations in OpenAlex.

  1. PEARL: Protein Eluting Alginate with Recombinant Lactobacilli.Small (Weinheim an der Bergstrasse, Germany) · 2026
    Article
  2. Article
  3. Review
  4. Delivering living medicines with biomaterials.Nature reviews. Materials · 2025
    Article
  5. Review
  6. Living Material with Temperature-Dependent Light Absorption.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Engineered Living Hydrogels.Advanced materials (Deerfield Beach, Fla.) · 2022
    Review
  12. Regulating Bacterial Behavior within Hydrogels of Tunable Viscoelasticity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022
    Article
  13. Article
  14. Engineered Bacteria-Based Living Materials for Biotherapeutic Applications.Frontiers in bioengineering and biotechnology · 2022
    Review
  15. Article
  16. Hybrid Living Capsules Autonomously Produced by Engineered Bacteria.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 3 institutions in 1 country.

Shuaiqi Guo
Emilien Dubuc
Yahav Rave
Mick Verhagen
Simone A E Twisk
Tim van der Hek
Guido J M Oerlemans
Maxime C M van den Oetelaar
Laura S van Hazendonk
Mariska Brüls
Bruno V Eijkens
Pim L Joostens
Sander R Keij
Weizhou Xing
Martijn NijsStichting PAMM, Laboratory for Pathology and Medical Microbiology, De Run 6250, Veldhoven, 5504 DL, The Netherlands.
Jitske StalpersStichting PAMM, Laboratory for Pathology and Medical Microbiology, De Run 6250, Veldhoven, 5504 DL, The Netherlands.
Manoj Sharma
Marieke Gerth
Roy J E A Boonen
Kees VerduinStichting PAMM, Laboratory for Pathology and Medical Microbiology, De Run 6250, Veldhoven, 5504 DL, The Netherlands.
Tom F A de GreefInstitute for Molecules and Materials, Radboud University, Heyendaalseweg 135, Nijmegen, 6525 AJ, The Netherlands.ORCID 0000-0002-9338-284X
Eindhoven University of Technology · NLPAMM · NLRadboud University Nijmegen · NL

Funding

Resource for Biocomputing Visualization and InformaticsP41GM103311 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERRIN, THOMAS E · 2012 to 2017
$8.2M
NIGMS NIH HHS P41 GM103311
6 · The paper itself

Abstract

Engineered living materials have the potential for wide-ranging applications such as biosensing and treatment of diseases. Programmable cells provide the functional basis for living materials; however, their release into the environment raises numerous biosafety concerns. Current designs that limit the release of genetically engineered cells typically involve the fabrication of multilayer hybrid materials with submicrometer porous matrices. Nevertheless the stringent physical barriers limit the diffusion of macromolecules and therefore the repertoire of molecules available for actuation in response to communication signals between cells and their environment. Here, we engineer a novel living material entitled "Platform for Adhesin-mediated Trapping of Cells in Hydrogels" (PATCH). This technology is based on engineered

Indexed as

Adhesins, BacterialAnti-Bacterial AgentsBiocompatible MaterialsCell MembraneDextransEscherichia coliGenetic EngineeringHydrogelsLysostaphinMarinomonasMaterials TestingMethicillin-Resistant Staphylococcus aureusAdhesins, BacterialAnti-Bacterial AgentsBiocompatible MaterialsDextransHydrogelsLysostaphin

Identifiers

PMID32105449
PMCPMC7091533
OpenAlexW3006887305

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.