Evidence map›Paper›PMID 32105366›Full record

ArticleProteins2020

Analyses of protein cores reveal fundamental differences between solution and crystal structures.

Zhe Mei, John D Treado, Alex T Grigas, Zachary A Levine, Lynne Regan, Corey S O'Hern

Abstract read
In one paragraph

Article in Proteins, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Residue burial encodes a protein's fold.bioRxiv : the preprint server for biology · 2026
    Article
  2. Article
  3. Article
  4. Target Engagement Assays in Early Drug Discovery.Journal of medicinal chemistry · 2025
    Review
  5. Re-engineering of a carotenoid-binding protein based on NMR structure.Protein science : a publication of the Protein Society · 2024
    Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Core packing of well-defined X-ray and NMR structures is the same.Protein science : a publication of the Protein Society · 2022
    Article
  12. Article
  13. Molecular Dynamics Simulations of a Cytochrome P450 fromMolecules (Basel, Switzerland) · 2021
    Article
  14. Using physical features of protein core packing to distinguish real proteins from decoys.Protein science : a publication of the Protein Society · 2020
    Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zhe MeiIntegrated Graduate Program in Physical & Engineering Biology, Yale University, New Haven, Connecticut.
John D TreadoIntegrated Graduate Program in Physical & Engineering Biology, Yale University, New Haven, Connecticut.
Alex T GrigasIntegrated Graduate Program in Physical & Engineering Biology, Yale University, New Haven, Connecticut.
Zachary A LevineDepartment of Pathology, Yale University, New Haven, Connecticut.
Lynne ReganInstitute of Quantitative Biology, Biochemistry and Biotechnology, Center for Synthetic and Systems Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, UK.
Corey S O'HernIntegrated Graduate Program in Physical & Engineering Biology, Yale University, New Haven, Connecticut.ORCID 0000-0002-8272-5640

Funding

PREDOCTORAL PROGRAM IN BIOPHYSICST32GM008283 · NIGMS · YALE UNIVERSITY · PI XIONG, YONG · 1988 to 2022
$10.5M
Predoctoral Program in BiophysicsT32GM149438 · NIGMS · YALE UNIVERSITY · PI Yong Xiong, Elsa Chui Ying Yan · 2023 to 2026
$2.6M
Convergent Graduate Training in Engineering, Physics and BiologyT32EB019941 · NIBIB · YALE UNIVERSITY · PI O'HERN, COREY · 2016 to 2020
$998k
NIBIB NIH HHS T32 EB019941NIBIB NIH HHS T32EB019941NIGMS NIH HHS T32 GM008283NIGMS NIH HHS T32 GM149438
6 · The paper itself

Abstract

There have been several studies suggesting that protein structures solved by NMR spectroscopy and X-ray crystallography show significant differences. To understand the origin of these differences, we assembled a database of high-quality protein structures solved by both methods. We also find significant differences between NMR and crystal structures-in the root-mean-square deviations of the C

Indexed as

Amino AcidsAmino Acid SequenceCrystallizationCrystallography, X-RayDatasets as TopicNuclear Magnetic Resonance, BiomolecularProtein ConformationProteinsSolutionsAmino AcidsProteinsSolutionscore packing fractionhigh-quality NMR structureshigh-resolution X-ray crystallographyhydrophobic amino acidsprotocol dependence

Identifiers

PMID32105366
PMCPMC7415476

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.