Evidence map›Paper›PMID 32105330›Full record

ReviewEndocrinology2020

Impact of Exogenous Testosterone on Reproduction in Transgender Men.

Molly B Moravek, Hadrian M Kinnear, Jenny George, Jourdin Batchelor, Ariella Shikanov, Vasantha Padmanabhan, John F Randolph

2 registry-linked trialsOpen access · bronzeAbstract readReview
In one paragraph

Review in Endocrinology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 36 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 1 pooled it
9.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06450405 phase4terminatednot on this mapstarted 2025, after this paper: background citation

Androgen Effects on the Reproductive Neuroendocrine Axis

TypeinterventionalSponsorUniversity of California, San DiegoRan2025 to 2025Enrolled2ConditionsTransgenderism, Reproductive IssuesArmsTestosterone Cypionate 50 MG/ML Injectable Solution
NCT07092527 phase4recruitingnot on this mapstarted 2025, after this paper: background citation

Androgen Effects on the Reproductive Neuroendocrine Axis, 2025 Version

TypeinterventionalSponsorUniversity of California, San DiegoRan2025 to 2028Enrolled80ConditionsTransgenderism, Reproductive IssuesArmsTestosterone Cypionate 50 milligrams per millileter (mg/mL) Injectable Solution
3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Observational
  5. Article
  6. Article
  7. Article
  8. iScience · 2025
    Article
  9. Article
  10. Social Representations of pregnancy among trans men.Revista brasileira de enfermagem · 2025
    Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Review
  17. Young Adults' Understanding of Modifiable Risk Factors of Infertility.Women's health reports (New Rochelle, N.Y.) · 2024
    Article
  18. Article
  19. Review
  20. Reproductive capacity after gender-affirming testosterone therapy.Human reproduction (Oxford, England) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Molly B MoravekDepartment of Obstetrics and Gynecology, University of Michigan, Ann Arbor, Michigan.
Hadrian M KinnearCellular and Molecular Biology Program, University of Michigan, Ann Arbor, Michigan.
Jenny GeorgeDepartment of Obstetrics and Gynecology, University of Michigan, Ann Arbor, Michigan.
Jourdin BatchelorUniversity of Michigan Medical School, Ann Arbor, Michigan.
Ariella ShikanovDepartment of Obstetrics and Gynecology, University of Michigan, Ann Arbor, Michigan.
Vasantha PadmanabhanDepartment of Obstetrics and Gynecology, University of Michigan, Ann Arbor, Michigan.
John F RandolphDepartment of Obstetrics and Gynecology, University of Michigan, Ann Arbor, Michigan.
University of Michigan · US

Funding

MICHIGAN MEDICAL SCIENTIST TRAINING PROGRAMT32GM007863 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI COLLINS, KATHLEEN L. · 1985 to 2024
$38.3M
Reproductive Consequences of Steroid Hormone AdministrationR01HD098233 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MORAVEK, MOLLY BENNETTE · 2019 to 2023
$2.6M
Career Training in Reproductive BiologyT32HD079342 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Suzanne M MOENTER · 2014 to 2026
$2.3M
Reversibility of Testosterone-Induced Reproductive Changes in Adult Female MiceF30HD100163 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KINNEAR, HADRIAN MYLES · 2019 to 2022
$178k
NICHD NIH HHS F30 HD100163NICHD NIH HHS R01 HD098233NICHD NIH HHS T32 HD079342NIGMS NIH HHS T32 GM007863
6 · The paper itself

Abstract

Studies show that a subset of transgender men desire children; however, there is a paucity of literature on the effect of gender-affirming testosterone therapy on reproductive function. In this manuscript, we will review the process of gender-affirming hormone therapy for transgender men and what is known about ovarian and uterine consequences of testosterone exposure in transgender men; draw parallels with existing animal models of androgen exposure; summarize the existing literature on parenting experiences and desires in transgender people; discuss considerations for assisted reproductive technologies and fertility preservation; and identify gaps in the literature and opportunities for further research.

Indexed as

Transgender PersonsAndrogensAnimalsFemaleGender-Affirming ProceduresGenitalia, FemaleHumansMaleModels, AnimalReproductionTestosteroneAndrogensTestosteronefertilitygender-affirming hormone therapyreproductiontransgender men

Identifiers

PMID32105330
PMCPMC7046016
OpenAlexW3008777930

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.