Evidence map›Paper›PMID 32105215›Full record

ArticleeLife2020

Homologue replacement in the import motor of the mitochondrial inner membrane of trypanosomes.

Corinne von Känel, Sergio A Muñoz-Gómez, Silke Oeljeklaus, Christoph Wenger, Bettina Warscheid, Jeremy G Wideman, Anke Harsman, Andre Schneider

Open access · goldAbstract read
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 29 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Corinne von KänelDepartment of Chemistry and Biochemistry, University of Bern, Bern, Switzerland.ORCID 0000-0002-2885-5161
Sergio A Muñoz-GómezCenter for Mechanisms of Evolution, Biodesign Institute, School of Life Sciences, Arizona State University, Tempe, United States.
Silke OeljeklausBiochemistry and Functional Proteomics, Institute of Biology II, Faculty of Biology and Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Freiburg, Germany.
Christoph WengerDepartment of Chemistry and Biochemistry, University of Bern, Bern, Switzerland.
Bettina WarscheidBiochemistry and Functional Proteomics, Institute of Biology II, Faculty of Biology and Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Freiburg, Germany.ORCID 0000-0001-5096-1975
Jeremy G WidemanCenter for Mechanisms of Evolution, Biodesign Institute, School of Life Sciences, Arizona State University, Tempe, United States.
Anke HarsmanDepartment of Chemistry and Biochemistry, University of Bern, Bern, Switzerland.
Andre SchneiderDepartment of Chemistry and Biochemistry, University of Bern, Bern, Switzerland.ORCID 0000-0001-5421-0909
University of Bern · CHArizona State University · USUniversity of Freiburg · DE

Funding

Deutsche Forschungsgemeinschaft 403222702/SFB 1381ERC Consolidator grant 648235European Research Council Consolidator grant 648235Excellence Initiative of the German Federal and State Governments EXC 294 BIOSSGermany's Excellence Strategy CIBSS - EXC-2189 - Project ID 390939984Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung 175563Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung NCCR RNA and DiseaseSwiss National Science Foundation 175563Swiss National Science Foundation NCCR RNA and Disease
6 · The paper itself

Abstract

Many mitochondrial proteins contain N-terminal presequences that direct them to the organelle. The main driving force for their translocation across the inner membrane is provided by the presequence translocase-associated motor (PAM) which contains the J-protein Pam18. Here, we show that in the PAM of

Indexed as

MitochondriaMitochondrial MembranesMolecular Motor ProteinsPhylogenyProtein BindingProtein TransportProtozoan ProteinsTrypanosoma brucei bruceiMolecular Motor ProteinsProtozoan Proteinsbiochemistrychemical biologyevolutionevolutionary biologyj domain containing proteinmitochondrial protein importpresequence translocaseTrypanosoma

Identifiers

PMID32105215
PMCPMC7064343
OpenAlexW3008406604

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.