Evidence map›Paper›PMID 32104839›Full record

ArticleChemical communications (Cambridge, England)2020

Template-guided selection of RNA ligands using imine-based dynamic combinatorial chemistry.

Aline Umuhire Juru, Zhengguo Cai, Adina Jan, Amanda E Hargrove

Open access · greenAbstract read
In one paragraph

Article in Chemical communications (Cambridge, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Gene drive that results in addiction to a temperature-sensitive version of an essential gene triggers population collapse inProceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  7. Small molecule-RNA targeting: starting with the fundamentals.Chemical communications (Cambridge, England) · 2020
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Aline Umuhire JuruDepartment of Chemistry, Duke University, 124 Science Drive, Durham, NC 27705, USA. amanda.hargrove@duke.edu.ORCID http://orcid.org/0000-0002-4059-6860
Zhengguo CaiDepartment of Chemistry, Duke University, 124 Science Drive, Durham, NC 27705, USA. amanda.hargrove@duke.edu.ORCID http://orcid.org/0000-0002-4819-2115
Adina JanDepartment of Chemistry, Duke University, 124 Science Drive, Durham, NC 27705, USA. amanda.hargrove@duke.edu.
Amanda E HargroveDepartment of Chemistry, Duke University, 124 Science Drive, Durham, NC 27705, USA. amanda.hargrove@duke.edu.ORCID http://orcid.org/0000-0003-1536-6753
Duke University · US

Funding

The Center for HIV RNA Studies (CRNA)U54AI150470 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI TELESNITSKY, ALICE · 2019 to 2021
$15.1M
NIAID NIH HHS U54 AI150470
6 · The paper itself

Abstract

This study establishes the applicability of imine-based dynamic combinatorial chemistry to discover non-covalent ligands for RNA targets. We elucidate properties underlying the reactivity of arylamines and demonstrate target-guided amplification of tight binders in an amiloride-based dynamic library.

Indexed as

AminesCombinatorial Chemistry TechniquesGenes, envHIV Long Terminal RepeatIminesLigandsRNAAminesIminesLigandsRNA

Identifiers

PMID32104839
PMCPMC7218690
OpenAlexW3007683007

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.