Evidence map›Paper›PMID 32104747›Full record

ArticleCurrent opinion in biomedical engineering2019

CELLULAR RESOLUTION IMAGING OF NEURONAL ACTIVITY ACROSS SPACE AND TIME IN THE MAMMALIAN BRAIN.

Mitchell Clough, Jerry L Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current opinion in biomedical engineering, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. No Central Executive? Decision Formation Through Multi-Area Population Dynamics.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Mitchell CloughDepartment of Biomedical Engineering, Boston University, Boston, USA.
Jerry L ChenDepartment of Biomedical Engineering, Boston University, Boston, USA.

Funding

Population Imaging of Action Potentials by Novel Two-Photon Microscopes and Genetically Encoded Voltage IndicatorsUF1NS107705 · NINDS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI CHEN, JERRY L, PIERIBONE, VINCENT A · 2018 to 2018
$2.7M
Cracking Genetically Defined Neocortical Circuits across Learning and BehaviorDP2NS111134 · NINDS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI CHEN, JERRY L · 2018 to 2022
$2.4M
Cortical Interactions Underlying Sensory RepresentationsR01NS109965 · NINDS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI CHEN, JERRY L · 2018 to 2022
$2.0M
NINDS NIH HHS DP2 NS111134NINDS NIH HHS R01 NS109965NINDS NIH HHS UF1 NS107705
6 · The paper itself

Abstract

While the action potential has long been understood to be the fundamental bit of information in brain, how these spikes encode representations of stimuli and drive behavior remains unclear. Large-scale neuronal recordings with cellular and spike-time resolution spanning multiple brain regions are needed to capture relevant network dynamics that can be sparse and distributed across the population. This review focuses on recent advancements in optical methods that have pushed the boundaries for simultaneous population recordings at increasing volumes, distances, depths, and speeds. The integration of these technologies will be critical for overcoming fundamental limits in the pursuit of whole brain imaging in mammalian species.

Identifiers

PMID32104747
PMCPMC7043406

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.