Evidence map›Paper›PMID 32104530›Full record

ArticleOxidative medicine and cellular longevity2020

The Antiaging Activity of Ergothioneine in UVA-Irradiated Human Dermal Fibroblasts via the Inhibition of the AP-1 Pathway and the Activation of Nrf2-Mediated Antioxidant Genes.

You-Cheng Hseu, Yugandhar Vudhya Gowrisankar, Xuan-Zao Chen, Yi-Chen Yang, Hsin-Ling Yang

Open access · hybridAbstract read
In one paragraph

Article in Oxidative medicine and cellular longevity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 69 citations in OpenAlex.

  1. Trial
  2. Review
  3. Review
  4. Review
  5. King Oyster Mushroom,Nutrients · 2026
    Article
  6. Enhanced production of ergothioneine in Aspergillus oryzae.Applied microbiology and biotechnology · 2025
    Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Review
  13. Effects of an ergothioneine-richFrontiers in medicine · 2024
    Article
  14. Article
  15. Review
  16. Review
  17. Review
  18. Review
  19. Molecules (Basel, Switzerland) · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

You-Cheng HseuDepartment of Cosmeceutics, College of Biopharmaceutical and Food Sciences, China Medical University, Taichung 40402, Taiwan.ORCID https://orcid.org/0000-0001-5307-6162
Yugandhar Vudhya GowrisankarDepartment of Cosmeceutics, College of Biopharmaceutical and Food Sciences, China Medical University, Taichung 40402, Taiwan.
Xuan-Zao ChenDepartment of Cosmeceutics, College of Biopharmaceutical and Food Sciences, China Medical University, Taichung 40402, Taiwan.
Yi-Chen YangDepartment of Cosmeceutics, College of Biopharmaceutical and Food Sciences, China Medical University, Taichung 40402, Taiwan.
Hsin-Ling YangInstitute of Nutrition, College of Biopharmaceutical and Food Sciences, China Medical University, Taichung 40402, Taiwan.ORCID https://orcid.org/0000-0002-3561-7372
China Medical University · TWAsia University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

UVA irradiation induced ROS-mediated photo damage to the human skin leading to coarseness, wrinkling, pigmentation, and cutaneous malignancies. We investigated the dermatoprotective efficacies of submicromolar concentrations of ergothioneine (EGT, 0.125-0.5

Indexed as

AntioxidantsCell LineErgothioneineFibroblastsGlutathioneHeme Oxygenase-1HumansMAP Kinase Signaling SystemNAD(P)H Dehydrogenase (Quinone)NF-E2-Related Factor 2ProcollagenProtein Kinase CReactive Oxygen SpeciesRNA, Small InterferingSignal TransductionSkin AgingAntioxidantsErgothioneineGlutathioneHeme Oxygenase-1HMOX1 protein, humanNAD(P)H Dehydrogenase (Quinone)NFE2L2 protein, humanNF-E2-Related Factor 2NQO1 protein, humanProcollagenProtein Kinase CReactive Oxygen SpeciesRNA, Small InterferingTranscription Factor AP-1

Identifiers

PMID32104530
PMCPMC7038158
OpenAlexW3005553488

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.