MIP-T3 Expression Associated with Defects of Ciliogenesis in Airway of COPD Patients.

Wen-Jun Wang, Shi-Fang Yang, Zhi-Rui Gao, Ze-Ru Luo, Yuan-Ling Liu, Xing-Lin Gao

Open access · goldAbstract read

In one paragraph

Article in Canadian respiratory journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.2field-weighted citation impact, top 41% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

Lianhua Qingke Preserves Mucociliary Clearance in Rat with Acute Exacerbation of Chronic Obstructive Pulmonary Disease by Maintaining Ciliated Cells Proportion and Protecting Structural Integrity and Beat Function of Cilia.International journal of chronic obstructive pulmonary disease · 2024
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Wen-Jun WangDepartment of Respiratory and Critical Care Medicine, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Guangdong Provincial Geriatrics Institute, First Clinical Medicine Institute of South China University of Technology, Guangzhou, Guangdong, China.

Shi-Fang YangDepartment of Respiratory and Critical Care Medicine, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Guangdong Provincial Geriatrics Institute, First Clinical Medicine Institute of South China University of Technology, Guangzhou, Guangdong, China.

Zhi-Rui GaoDepartment of Respiratory and Critical Care Medicine, Yan'an Hospital of Kunming, Kunming, China.

Ze-Ru LuoDepartment of Respiratory and Critical Care Medicine, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Guangdong Provincial Geriatrics Institute, First Clinical Medicine Institute of South China University of Technology, Guangzhou, Guangdong, China.

Yuan-Ling LiuDepartment of Respiratory and Critical Care Medicine, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Guangdong Provincial Geriatrics Institute, First Clinical Medicine Institute of South China University of Technology, Guangzhou, Guangdong, China.

Xing-Lin GaoDepartment of Respiratory and Critical Care Medicine, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Guangdong Provincial Geriatrics Institute, First Clinical Medicine Institute of South China University of Technology, Guangzhou, Guangdong, China.ORCID 0000-0003-1440-2126

Guangdong Academy of Medical Sciences · CNKunming Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: This study aimed at exploring the dominated structural abnormalities of cilia and the involvement of MIP-T3 in the pathogenesis of cilia of COPD patients. Methods: Patients who accepted pulmonary lobectomy were divided into 3 groups: the chronic obstructive pulmonary disease (COPD) smoker group, the healthy smoker group, and the nonsmoker group, according to smoking history and pulmonary function. The ultrastructure of cilia and the percentage of abnormal cilia were analyzed using a transmission electron microscope. Real-time PCR, immunohistochemical staining, and western blotting in bronchial epithelium were used to determine MIP-T3 mRNA and protein expression. The relationship between the percentage of abnormal cilia and lung function and MIP-T3 protein expression was analyzed. Results: Patients in the COPD smoker group had increased percentage of abnormal cilia comparing to both the healthy smoker group and the nonsmoker group (both Conclusions: Our results suggested that the abnormal ciliary ultrastructure, which was common in COPD patients, might be due to MIP-T3 downregulation.

Indexed as

CiliaPulmonary Disease, Chronic ObstructiveSmokingDown-RegulationFemaleGene Expression ProfilingHumansImmunohistochemistryMaleMicroscopy, Electron, TransmissionMicrotubule-Associated ProteinsMiddle AgedRespiratory Function TestsRespiratory MucosaMicrotubule-Associated ProteinsTRAF3IP1 protein, human

Identifiers

PMID32104517

DOI10.1155/2020/1350872

PMCPMC7035511

OpenAlexW3006417622

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.