Evidence map›Paper›PMID 32104516›Full record

ReviewBehavioural neurology2020

Potential Benefits of Physical Activity in MCI and Dementia.

Hallie Nuzum, Ariana Stickel, Maria Corona, Michelle Zeller, Rebecca J Melrose, Stacy Schantz Wilkins

Registry-linked trialOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Behavioural neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07616050 (Evaluation of the Impact of a Rehabilitation Intervention Based on Cycling With Virtual Park on Training Motivation in Adult Patients), which is not on this map. Cited by 129 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
129citing papers in PubMed, 11 pooled it
19.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07616050 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Evaluation of the Impact of a Rehabilitation Intervention Based on Cycling With Virtual Park on Training Motivation in Adult Patients

TypeinterventionalSponsorMarta MondelliniRan2026 to 2027Enrolled70ConditionsPost-stroke, Parkinson Disease, Amyotrophic Lateral Sclerosis, Mild Cognitive Impairment (MCI)ArmsDual-task training with Virtual Reality, Cycling training
3 · Its place in the literature

Who cites it

129 citing papers in PubMed, 11 syntheses or guidelines pooled it, 240 citations in OpenAlex.

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  16. Hesperetin Rescues Amyloid Beta-Induced Defects in Neurite Outgrowth UnderInternational journal of molecular sciences · 2026
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  17. Review
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  20. Is the 10-Year Trajectory of Physical Activity Associated With the Incidence of Mild Cognitive Impairment in Older Adults?Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society · 2026
    Article

69 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Hallie NuzumVA Greater Los Angeles Medical Center, Los Angeles, CA, USA.ORCID https://orcid.org/0000-0002-9658-4885
Ariana StickelVA Greater Los Angeles Medical Center, Los Angeles, CA, USA.ORCID https://orcid.org/0000-0002-6312-2377
Maria CoronaVA Greater Los Angeles Medical Center, Los Angeles, CA, USA.
Michelle ZellerVA Greater Los Angeles Medical Center, Los Angeles, CA, USA.ORCID https://orcid.org/0000-0002-3277-1286
Rebecca J MelroseVA Greater Los Angeles Medical Center, Los Angeles, CA, USA.
Stacy Schantz WilkinsVA Greater Los Angeles Medical Center, Los Angeles, CA, USA.
Los Angeles Medical Center · USUniversity of California, Los Angeles · USUniversity of Arizona · USUniversity of Notre Dame · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Physical activity improves overall health and reduces the risk of many negative health outcomes and may be effective in improving cognition, independent functioning, and psychological health in older adults. Given the evidence linking physical activity with improvements in various aspects of health and functioning, interventions exploring pathways for decreasing risk of dementia in those with mild cognitive impairment (MCI) and improving outcomes for those with dementia are of critical importance. The present review highlights the work examining physical activity interventions in order to achieve a comprehensive understanding of the potential benefits of physical activity for individuals experiencing cognitive decline. The primary focus is on aerobic exercise as this is the main intervention in the literature. Our review supports the thesis that physical activity can promote healthy aging in terms of cognition, independent functioning, and psychological health for individuals experiencing cognitive decline. Specifically, physical activity improves cognition, especially executive functioning and memory in MCI, independent functioning in MCI and dementia, and psychological health in dementia. Given that benefits of physical activity have been observed across these domains, such interventions provide an avenue for preventing decline and/or mitigating impairment across several domains of functioning in older adults with MCI or dementia and may be recommended (and adjusted) for patients across a range of settings, including medical and mental health settings. Further implications for clinical intervention and future directions for research are discussed.

Indexed as

AgedAged, 80 and overCognitionCognitive DysfunctionDementiaExecutive FunctionExerciseExercise TherapyFemaleHumansMaleMiddle Aged

Identifiers

PMID32104516
PMCPMC7037481
OpenAlexW3005680437

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.