Evidence map›Paper›PMID 32104480›Full record

ArticleAsian journal of pharmaceutical sciences2019

Redox-sensitive micelles for targeted intracellular delivery and combination chemotherapy of paclitaxel and all-trans-retinoid acid.

Lingfei Han, Lejian Hu, Fulei Liu, Xin Wang, Xiaoxian Huang, Bowen Liu, Feng Feng, Wenyuan Liu, Wei Qu

Open access · diamondAbstract read
In one paragraph

Article in Asian journal of pharmaceutical sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 39 citations in OpenAlex.

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  9. Article
  10. Targeting Strategies for Enhancing Paclitaxel Specificity in Chemotherapy.Frontiers in cell and developmental biology · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Lingfei HanDepartment of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing 210009, China.
Lejian HuDepartment of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China.
Fulei LiuDepartment of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China.
Xin WangDepartment of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing 210009, China.
Xiaoxian HuangDepartment of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China.
Bowen LiuDepartment of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China.
Feng FengDepartment of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China.
Wenyuan LiuDepartment of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing 210009, China.
Wei QuDepartment of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China.
China Pharmaceutical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The application of paclitaxel (PTX) in clinic has been restricted due to its poor solubility. Several traditional nano-medicines have been developed to improve this defect, while they are still lack of tumor targeting ability and rapid drug release. In this work, an amphiphilic polymeric micelle of hyaluronic acid (HA) - all-trans-retinoid acid (ATRA) with a disulfide bond, was developed successfully for the co-delivery of PTX and ATRA. The combination chemotherapy of PTX and ATRA can strengthen the anti-tumor activity. Along with self-assembling to micelles in water, the delivery system displayed satisfying drug loading capacities for both PTX (32.62% ± 1.39%) and ATRA, due to directly using ATRA as the hydrophobic group. Rapid drug release properties of the PTX-loaded redox-sensitive micelles (HA-SS-ATRA)

Indexed as

All-trans-retinoid acidCombination chemotherapyHyaluronic acidRedox-sensitiveTumor targeting

Identifiers

PMID32104480
PMCPMC7032146
OpenAlexW2892490032

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.