ArticleAsian journal of pharmaceutical sciences2019
Co-amorphous solid dispersion systems of lacidipine-spironolactone with improved dissolution rate and enhanced physical stability.
Article in Asian journal of pharmaceutical sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- The Impact of Sugar Moieties on the Solubility of Naringin-Neohesperidin Co-Amorphous Solid Dispersions.Pharmaceutics · 2026Article
- Considerations and Challenges to Develop Drug-drug Coamorphous System: A Recent Update.Current pharmaceutical biotechnology · 2025Review
- Amorphous Solid Dispersions of Glycyrrhetinic Acid: Using Soluplus, PVP, and PVPVA as the Polymer Matrix to Enhance Solubility, Bioavailability, and Stability.AAPS PharmSciTech · 2024Article
- Formulating abiraterone acetate-HPMCAS-based amorphous solid dispersions: insights intoRSC advances · 2024Article
- Preparation and Characterization of Lutein Co-Amorphous Formulation with Enhanced Solubility and Dissolution.Foods (Basel, Switzerland) · 2024Article
- Influence of Intermolecular Interactions on Crystallite Size in Crystalline Solid Dispersions.Pharmaceutics · 2023Article
- A Comparative Assessment of Cocrystal and Amorphous Solid Dispersion Printlets Developed by Hot Melt Extrusion Paired Fused Deposition Modeling for Dissolution Enhancement and Stability of Ibuprofen.AAPS PharmSciTech · 2023Article
- Continuous Manufacturing and Molecular Modeling of Pharmaceutical Amorphous Solid Dispersions.AAPS PharmSciTech · 2022Review
- Deaggregation and Crystallization Inhibition by Small Amount of Polymer Addition for a Co-Amorphous Curcumin-Magnolol System.Pharmaceutics · 2021Article
- Pulmonary Drug Delivery of Antimicrobials and Anticancer Drugs Using Solid Dispersions.Pharmaceutics · 2021Review
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Authors and funding
10 authors.
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Abstract
Co-amorphous solid dispersion (C-ASD) systems have attracted great attention to improve the solubility of poorly soluble drugs, but the selection of an appropriate stabilizer to stabilize amorphous forms is still a huge challenge. Herein, C-ASD system of two clinical combined used drugs (lacidipine (LCDP) and spironolactone (SPL)) as stabilizers to each other, was prepared by solvent evaporation method. The effects of variation in molar ratio of LCDP and SPL (3:1, 1:1, 1:3, 1:6, and 1:9) on the drug release characteristics were explored. Polarized light microscopy (PLM), powder X-ray diffraction (PXRD), differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA) were employed to evaluate the solid states. Prepared C-ASDs were further studied for their stability under the high humidity (RH 92.5%). Further analysis of C-ASDs via Fourier-transform infrared spectroscopy (FTIR) and Raman spectroscopy confirmed that hydrogen bond interactions between the two drugs played a significant role in maintaining the stability of the C-ASDs systems. Moreover, molecular dynamic (MD) simulations provided a clear insight into the stability mechanism at the molecular level. This study demonstrated the novel drug-drug C-ASDs systems is a promising formulation strategy for improved dissolution rate and enhanced physical stability of poorly soluble drugs.
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