Evidence map›Paper›PMID 32104204›Full record

ArticleEcancermedicalscience2020

VUS-type alteration in POLD1 and microsatellite instability in a metastatic luminal B breast cancer patient.

Catarina Marchon da Silva, Denis Shimba, Denise Oishi, Allyne Cagnacci, Ana Carolina Ribeiro Chaves de Gouvea, Felipe Ades

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Ecancermedicalscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Catarina Marchon da SilvaFaculdade de Medicina, Universidade Municipal de São Caetano do Sul, São Caetano do Sul, SP 09521-160, Brazil.
Denis ShimbaCentro Especializado em Oncologia, Hospital Alemão Oswaldo Cruz, São Paulo, SP 01323-020, Brazil.
Denise OishiCentro Especializado em Oncologia, Hospital Alemão Oswaldo Cruz, São Paulo, SP 01323-020, Brazil.
Allyne CagnacciCentro Especializado em Oncologia, Hospital Alemão Oswaldo Cruz, São Paulo, SP 01323-020, Brazil.
Ana Carolina Ribeiro Chaves de GouveaCentro Especializado em Oncologia, Hospital Alemão Oswaldo Cruz, São Paulo, SP 01323-020, Brazil.
Felipe AdesCentro Especializado em Oncologia, Hospital Alemão Oswaldo Cruz, São Paulo, SP 01323-020, Brazil.
Hospital Alemão Oswaldo Cruz · BRUniversidade Municipal de São Caetano do Sul · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Microsatellite instability (MSI) and POLD1 mutations are usually described in colorectal tumours in patients with polyposis syndrome but rarely found in breast tumours. This case describes a metastatic luminal B breast tumour in a young patient with an important family history of cancer. Mutational studies found a Variant of Uncertain Significance (VUS)-type alteration in POLD1 that motivated the study for MSI, which was found positive. Recent data point towards the use of pembrolizumab as a treatment option for tumour presenting with MSI instead of chemotherapy.

Indexed as

luminal B breast cancermicrosatellite instabilitypembrolizumabPOLD1

Identifiers

PMID32104204
PMCPMC7039690
OpenAlexW3002403551

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.