ReviewCancer management and research2020
Anesthetic Strategies in Oncological Surgery: Not Only a Simple Sleep, but Also Impact on Immunosuppression and Cancer Recurrence.
Review in Cancer management and research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- Comparison of the effects of remimazolam tosylate and propofol on immune function and hemodynamics in patients undergoing laparoscopic partial hepatectomy: a randomized controlled trial.BMC anesthesiology · 2024Trial
- Postoperative Care and Management in Pediatric Hematology-Oncology Patients.European journal of haematology · 2026Review
- Article
- The Impacts of Local Anesthetics and Surgical Trauma on Immunity.Veterinary medicine international · 2026Review
- The impact of perioperative anesthesia management-induced immunosuppression on postoperative cancer recurrence and metastasis: a narrative review.Frontiers in oncology · 2025Review
- A Nomogram for Predicting Pulmonary Complications Following Laparoscopic Surgery in Elderly Patients After the COVID-19 Pandemic.Clinical interventions in aging · 2025Article
- Article
- Propofol mediates non-small cell lung cancer growth in part by regulating circ_0003028-related mechanisms.Thoracic cancer · 2023Article
- The international clinical trials registry platform (ICTRP): data integrity and the trends in clinical trials, diseases, and drugs.Frontiers in pharmacology · 2023Article
- Article
- Anesthetic propofol suppresses growth and metastasis of lung adenocarcinoma in vitro through downregulating circ-MEMO1-miR-485-3p-NEK4 ceRNA axis.Histology and histopathology · 2022Article
- Effect of intravenous lidocaine infusion on perioperative cellular immunity and the quality of postoperative recovery in breast cancer patients: a randomized controlled trial.Gland surgery · 2022Article
- The benefits of propofol on cancer treatment: Decipher its modulation code to immunocytes.Frontiers in pharmacology · 2022Review
- Effect of Propofol or Etomidate as General Anaesthesia Induction on Gastric Cancer: A Retrospective Cohort Study with 10 Years' Follow-Up.Cancer management and research · 2022Article
- Number of transurethral procedures after non-muscle-invasive bladder cancer and survival in causes other than bladder cancer.PloS one · 2022Article
- Sevoflurane promotes the apoptosis of laryngeal squamous cell carcinoma in-vitro and inhibits its malignant progression via miR-26a/FOXO1 axis.Bioengineered · 2021Article
- Effect of Dexmedetomidine on Biochemical Recurrence in Patients after Robot-Assisted Laparoscopic Radical Prostatectomy: A Retrospective Study.Journal of personalized medicine · 2021Article
- Optimal adjuvant chemotherapy completion time for stage III colon cancer: a cohort study.Journal of gastrointestinal oncology · 2021Article
- Informed consent and a risk-based approach to oncologic surgery in a cancer center during the COVID-19 pandemic.Journal of surgical oncology · 2021Article
- Sleeping Beauty: Anesthesia May Promote Relapse in Dogs With Diffuse Large B-Cell Lymphoma in Complete Remission After Chemo-Immunotherapy.Frontiers in veterinary science · 2021Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tumor recurrences or metastases remain a major hurdle in improving overall cancer survival. In the perioperative period, the balance between the ability of the cancer to seed and grow at the metastatic site and the ability of the patient to fight against the tumor (i.e. the host antitumor immunity) may determine the development of clinically evident metastases and influence the patient outcome. Up to 80% of oncological patients receive anesthesia and/or analgesia for diagnostic, therapeutic or palliative interventions. Therefore, anesthesiologists are asked to administer drugs such as opiates and volatile or intravenous anesthetics, which may determine different effects on immunomodulation and cancer recurrence. For instance, some studies suggest that intravenous drugs, such as propofol, may inhibit the host immunity to a lower extent as compared to volatile anesthetics. Similarly, some studies suggest that analgesia assured by local anesthetics may provide a reduction of cancer recurrence rate; whilst on the opposite side, opioids may exert negative consequences in patients undergoing cancer surgery, by interacting with the immune system response via the modulation of the hypothalamic-pituitary-adrenal axis and autonomic nervous system, or directly through the opioid receptors on the surface of immune cells. In this review, we summarize the main findings on the effects induced by different drugs on immunomodulation and cancer recurrence.
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