Evidence map›Paper›PMID 32103928›Full record

Observational studyInternational journal of chronic obstructive pulmonary disease2020

Statin Use and the Risk of Subsequent Hospitalized Exacerbations in COPD Patients with Frequent Exacerbations.

Chieh-Mo Lin, Tsung-Ming Yang, Yao-Hsu Yang, Ying-Huang Tsai, Chuan-Pin Lee, Pau-Chung Chen, Wen-Cheng Chen, Meng-Jer Hsieh

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in International journal of chronic obstructive pulmonary disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.9field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

  • Commented on by
    2020
5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Chieh-Mo LinDepartment of Pulmonary and Critical Care Medicine, Chiayi Chang Gung Memorial Hospital, Chang Gung Medical Foundation, Chiayi, Taiwan.ORCID 0000-0002-7811-6578
Tsung-Ming YangDepartment of Pulmonary and Critical Care Medicine, Chiayi Chang Gung Memorial Hospital, Chang Gung Medical Foundation, Chiayi, Taiwan.ORCID 0000-0002-9241-2816
Yao-Hsu YangDepartment of Traditional Chinese Medicine, Chiayi Chang Gung Memorial Hospital, Chang Gung Medical Foundation, Chiayi, Taiwan.ORCID 0000-0002-8080-0504
Ying-Huang TsaiDepartment of Pulmonary and Critical Care Medicine, Linkou Chang Gung Memorial Hospital, Chang Gung Medical Foundation, Taoyuan, Taiwan.
Chuan-Pin LeeHealth Information and Epidemiology Laboratory of Chang Gung Memorial Hospital, Chang Gung Medical Foundation, Chiayi, Taiwan.
Pau-Chung ChenInstitute of Environmental and Occupational Health Sciences, National Taiwan University College of Public Health, Taipei, Taiwan.ORCID 0000-0002-6242-5974
Wen-Cheng ChenDepartment of Radiation Oncology, Chiayi Chang Gung Memorial Hospital, Chang Gung Medical Foundation, Chiayi, Taiwan.
Meng-Jer HsiehDepartment of Pulmonary and Critical Care Medicine, Chiayi Chang Gung Memorial Hospital, Chang Gung Medical Foundation, Chiayi, Taiwan.ORCID 0000-0002-2077-0470
Chang Gung University · TWChiayi Chang Gung Memorial Hospital · TWNational Taiwan University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rationale: The potential benefits of statins for the prevention of exacerbations in patients with COPD remains controversial. No previous studies have investigated the impact of statins on clinical outcomes in COPD patients with frequent exacerbations. Objective: This study aimed to evaluate the association between the use of statins and the risk of subsequent hospitalized exacerbations in COPD frequent exacerbators. Materials and Methods: We conducted a population-based cohort study using the Taiwan National Health Insurance Research Database. 139,223 COPD patients with a first hospitalized exacerbation between 2004 and 2012 were analyzed. Among them, 35,482 had a second hospitalized exacerbation within a year after the first exacerbation, and were defined as frequent exacerbators. 1:4 propensity score matching was used to create matched samples of statin users and non-users. The competing risk regression analysis model was used to evaluate the association between statin use and exacerbation risk. Results: The use of statins was associated with a significantly reduced risk in subsequent hospitalized exacerbations in COPD patients after their first hospitalized exacerbation (adjusted subdistribution hazard ration [SHR], 0.89; 95% CI, 0.85-0.93, Conclusion: The use of statins was associated with a significant reduction in the risk of hospitalized exacerbations in COPD patients after a first hospitalized exacerbation and in specified COPD frequent exacerbators.

Indexed as

HospitalizationAdultAgedAged, 80 and overDatabases, FactualDisease ProgressionFemaleHumansHydroxymethylglutaryl-CoA Reductase InhibitorsMaleMiddle AgedPrognosisPulmonary Disease, Chronic ObstructiveRespiratory System AgentsRetrospective StudiesRisk AssessmentHydroxymethylglutaryl-CoA Reductase InhibitorsRespiratory System Agentschronic obstructive pulmonary diseaseexacerbationfrequent exacerbatorstatin

Identifiers

PMID32103928
PMCPMC7020922
OpenAlexW3004446958

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.