Evidence map›Paper›PMID 32103756›Full record

Trial reportJournal of translational medicine2020

Effects of a ketogenic diet in overweight women with polycystic ovary syndrome.

Antonio Paoli, Laura Mancin, Maria Cristina Giacona, Antonino Bianco, Massimiliano Caprio

3 registry-linked trialsOpen access · goldAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of translational medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 138 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
138citing papers in PubMed, 5 pooled it
17.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04163120 nacompletednot on this map

Effects of a Low Calorie Mediterranean Ketogenic Diet in Women With Polycystic Ovary Syndrome

TypeinterventionalSponsorUniversity of PadovaRan2017 to 2017Enrolled14ConditionsPolycystic Ovary SyndromeArmsLow calorie Mediterranean ketogenic diet with phytoextracts (KEMEPHY)
NCT06049186 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Comparison of Live Birth Rates Between Calorie-restricted Diets and Metformin Interventions Prior to Ovulation Induction Therapy in Patients With Overweight/Obese Polycystic Ovary Syndrome Combined With Infertility

TypeinterventionalSponsorShanghai First Maternity and Infant HospitalRan2023 to 2026Enrolled406ConditionsPolycystic Ovary SyndromeArmsCRD, Metformin
NCT06469255 nacompletednot on this map

Effects of Short-Term Low-Calorie Ketogenic Diet on Biochemical and Anthropometric Parameters in Women With Polycystic Ovary Syndrome

TypeinterventionalSponsorIstanbul Bilgi UniversityRan2019 to 2020Enrolled13ConditionsPolycystic Ovary SyndromeArmsDiet Treatment
3 · Its place in the literature

Who cites it

138 citing papers in PubMed, 5 syntheses or guidelines pooled it, 264 citations in OpenAlex.

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78 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Antonio PaoliDepartment of Biomedical Sciences, University of Padua, Padua, Italy. antonio.paoli@unipd.it.ORCID 0000-0003-0474-4229
Laura MancinDepartment of Biomedical Sciences, University of Padua, Padua, Italy.
Maria Cristina GiaconaDepartment of Neuroscience, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.
Antonino BiancoDepartment of Psychology, Educational Science and Human Movement, University of Palermo, Palermo, Italy.
Massimiliano CaprioLaboratory of Cardiovascular Endocrinology, IRCCS San Raffaele Pisana, Rome, Italy.
University of Padua · ITIRCCS Ospedale San Raffaele · ITUniversity of Palermo · ITUniversity of Verona · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPolycystic ovary syndrome (PCOS) is the most common endocrine disorder in women during reproductive age. It is characterised clinically by oligo-ovulation or anovulation, hyper-androgenism, and the presence of polycystic ovaries. It is associated with an increased prevalence of metabolic syndrome, cardiovascular disease and type 2 diabetes. The onset of PCOS has been associated to several hereditary and environmental factors, but insulin resistance plays a key pathogenetic role. We sought to investigate the effects of a ketogenic diet (KD) on women of childbearing age with a diagnosis of PCOS.

methodsFourteen overweight women with diagnosis of PCOS underwent to a ketogenic Mediterranean diet with phyoextracts (KEMEPHY) for 12 week. Changes in body weight, body mass index (BMI), fat body mass (FBM), lean body mass (LBM), visceral adipose tissue (VAT), insulin, glucose, HOMA-IR, total cholesterol, low density lipoprotein (LDL), high density lipoprotein (HDL), triglycerides (TGs), total and free testosterone, luteinizing hormone (LH), follicle stimulating hormone (FSH); dehydroepiandrosterone sulfate (DHEAs), estradiol, progesterone, sex hormone binding globulin (SHBG) and Ferriman Gallwey score were evaluated.

resultsAfter 12 weeks, anthropometric and body composition measurements revealed a significant reduction of body weight (- 9.43 kg), BMI (- 3.35), FBM (8.29 kg) and VAT. There was a significant, slightly decrease of LBM. A significant decrease in glucose and insulin blood levels were observed, together with a significant improvement of HOMA-IR. A significant decrease of triglycerides, total cholesterol and LDL were observed along with a rise in HDL levels. The LH/FSH ratio, LH total and free testosterone, and DHEAS blood levels were also significantly reduced. Estradiol, progesterone and SHBG increased. The Ferriman Gallwey Score was slightly, although not significantly, reduced.

conclusionsOur results suggest that a KD may be considered as a valuable non pharmacological treatment for PCOS. Longer treatment periods should be tested to verify the effect of a KD on the dermatological aspects of PCOS. Trial registration Clinicaltrial.gov, NCT04163120, registrered 10 November 2019, retrospectively registered, https://clinicaltrials.gov.

Indexed as

Diabetes Mellitus, Type 2Diet, KetogenicInsulin ResistancePolycystic Ovary SyndromeBody Mass IndexFemaleHumansInsulinLuteinizing HormoneOverweightInsulinLuteinizing HormoneHyperinsulinemiaKetogenic dietKetone bodiesLCKDLow carbohydrate dietOverweightPCOS

Identifiers

PMID32103756
PMCPMC7045520
OpenAlexW3010567443

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.