Evidence map›Paper›PMID 32103735›Full record

Observational studyBMC medical imaging2020

Radiological evaluation in patients with clinical suspicion of cerebral venous sinus thrombosis presenting with nontraumatic headache - a retrospective observational study with a validation cohort.

Håkan Almqvist, Michael Mazya, Alberto Falk Delgado, Anna Falk Delgado

Open access · goldAbstract readObservational Study
In one paragraph

Observational study in BMC medical imaging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Reducing the global burden of cerebral venous thrombosis: An international research agenda.International journal of stroke : official journal of the International Stroke Society · 2024
    Review
  5. Article
  6. Article
  7. Superior sagittal sinus thrombosis after spinal anesthesia.Neurosciences (Riyadh, Saudi Arabia) · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Håkan AlmqvistDepartment of Clinical Neuroscience, Karolinska Institutet, 17176, Stockholm, Solna, Sweden.
Michael MazyaDepartment of Clinical Neuroscience, Karolinska Institutet, 17176, Stockholm, Solna, Sweden.
Alberto Falk DelgadoDepartment of Surgical Sciences, Uppsala University, Uppsala, Sweden.
Anna Falk DelgadoDepartment of Clinical Neuroscience, Karolinska Institutet, 17176, Stockholm, Solna, Sweden. anna.falk-delgado@neuroradkarolinska.se.ORCID 0000-0003-4389-5089
Karolinska University Hospital · SEUppsala University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundClinical suspicion of cerebral venous sinus thrombosis (CVST) is imprecise due to non-specific symptoms such as headache. The aim was to retrospectively assess the diagnostic value of nonenhanced CT (neCT) in patients with nontraumatic headache and clinically suspected CVST.

methodsA retrospective consecutive series of patients referred 2013-2015 for radiology were evaluated. Eligible patients had nontraumatic headache and suspicion of CVST stated in the referral, investigated with CT venography (CTV) and nonenhanced CT (neCT). neCT scans were re-evaluated for the presence of CVST or other pathology. All CTVs were checked for the presence of CVST. The validation cohort consisted of 10 patients with nontraumatic CVT (2017-2019).

resultsLess than 1% (1/104) had a suspected thrombus on neCT, confirmed by subsequent CTV. The remaining 99% had a CTV excluding CVST. Eleven percent had other imaging findings explaining their symptoms. In the patient with CVST, the thrombosed dural sinus was high attenuating (maximum HU 89) leading to the suspicion of CVST confirmed by CTV. The validation cohort (n = 10) confirmed the presence of a high attenuating (HU > 65) venous structure in the presence of a confirmed thrombus in all patients presenting within 10 days (suspicion written in referral, 10%).

conclusionsDespite clinical suspicion, imaging findings of CVST in nontraumatic headache are uncommon. Evaluating neCT for high attenuation in dural sinuses, followed by CTV for confirmation in selected cases seems reasonable. CVST should be recognized by all radiologists and requires a high level of awareness when reading neCT for other indications.

Indexed as

AdultComputed Tomography AngiographyFemaleHeadacheHumansMaleMiddle AgedPhlebographyRadiographic Image Interpretation, Computer-AssistedRetrospective StudiesSensitivity and SpecificitySinus Thrombosis, IntracranialTomography, X-Ray ComputedCerebral venous sinus thrombosis (CVST)Diagnostic accuracyHeadacheHigh-attenuatingNonenhanced computed tomography

Identifiers

PMID32103735
PMCPMC7045590
OpenAlexW3012707875

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.