Evidence map›Paper›PMID 32103677›Full record

ArticleAntioxidants & redox signaling2020

Nix-Mediated Mitophagy Modulates Mitochondrial Damage During Intestinal Inflammation.

Garret Vincent, Elizabeth A Novak, Vei Shaun Siow, Kellie E Cunningham, Brian D Griffith, Thomas E Comerford, Heather L Mentrup, Donna B Stolz, Patricia Loughran, Sarangarajan Ranganathan and 1 more

Open access · greenAbstract read
In one paragraph

Article in Antioxidants & redox signaling, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 1 pooled it
4.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.

  1. Role of Mitochondria in Inflammatory Bowel Diseases: A Systematic Review.International journal of molecular sciences · 2023
    Pooled it
  2. Review
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  5. Article
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  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. The Dual Role of Exogenous Hydrogen Sulfide (HAntioxidants (Basel, Switzerland) · 2025
    Article
  15. Article
  16. Review
  17. Mitochondrial function and gastrointestinal diseases.Nature reviews. Gastroenterology & hepatology · 2024
    Review
  18. Article
  19. Review
  20. Recombinant probioticFrontiers in microbiology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Garret VincentDivision of Pediatric Surgery; Pittsburgh, Pennsylvania, USA.
Elizabeth A NovakDivision of Pediatric Surgery; Pittsburgh, Pennsylvania, USA.
Vei Shaun SiowDepartment of Surgery and University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Kellie E CunninghamDepartment of Surgery and University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Brian D GriffithDivision of Pediatric Surgery; Pittsburgh, Pennsylvania, USA.
Thomas E ComerfordDivision of Pediatric Surgery; Pittsburgh, Pennsylvania, USA.
Heather L MentrupDivision of Pediatric Surgery; Pittsburgh, Pennsylvania, USA.
Donna B StolzDepartment of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Patricia LoughranDepartment of Surgery and University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Sarangarajan RanganathanDepartment of Pathology; UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Kevin P MollenDivision of Pediatric Surgery; Pittsburgh, Pennsylvania, USA.
University of Pittsburgh · US

Funding

Mitonuclear Communication During the Pathogenesis of Inflammatory Bowel DiseaseR01DK120986 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Kevin P Mollen · 2020 to 2026
$3.0M
Mitochondrial Failure in the Pathogenesis of Inflammatory Bowel DiseaseK08DK101753 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MOLLEN, KEVIN P · 2014 to 2018
$764k
PGC1a Downregulation Contributes to the Pathogenesis of Inflammatory Bowel DiseaseR03DK114464 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MOLLEN, KEVIN P · 2018 to 2019
$156k
NIDDK NIH HHS K08 DK101753NIDDK NIH HHS R01 DK120986NIDDK NIH HHS R03 DK114464
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsAntioxidantsBinding SitesBiomarkersCell Line, TumorColitisCyclic N-OxidesDisease Models, AnimalDisease SusceptibilityGastroenteritisHumansHypoxiaHypoxia-Inducible Factor 1, alpha SubunitInflammatory Bowel DiseasesIntestinal MucosaMaleAntioxidantsBiomarkersCyclic N-OxidesHif1a protein, mouseHypoxia-Inducible Factor 1, alpha SubunitMap1lc3b protein, mouseMembrane ProteinsMicrotubule-Associated ProteinsMitochondrial ProteinsNix protein, mouseReactive Oxygen SpeciesTEMPOHIF1αhypoxiainflammatory bowel diseasereactive oxygen species

Identifiers

PMID32103677
PMCPMC7262642
OpenAlexW3008204732

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.