ArticleInflammation2020
Titanium Ions Play a Synergistic Role in the Activation of NLRP3 Inflammasome in Jurkat T Cells.
Article in Inflammation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 32 citations in OpenAlex.
- The immune-microbe-metal triad: a vicious cycle driving biomaterial corrosion in the oral inflammatory microenvironment.Bioactive materials · 2027Review
- Ferroptosis in orthopedic implant integration after oncologic surgery.Frontiers in oncology · 2026Review
- Titanium Dental Implant Corrosion in Peri-Implantitis and Implant Failure.Advances in experimental medicine and biology · 2026Review
- Review
- Cross-talk between NLRP3 and AIM2 inflammasomes in macrophage activation by LPS and titanium ions.Molecular medicine (Cambridge, Mass.) · 2025Article
- The impact of biocorrosion and titanium ions release on peri-implantitis.Clinical oral investigations · 2025Review
- Titanium particle-induced inflammasome in human gingival epithelial cells.Journal of dental sciences · 2025Article
- NLRP3 and AIM2 inflammasomes expression is modified by LPS and titanium ions increasing the release of active IL-1β in alveolar bone-derived MSCs.Stem cells translational medicine · 2024Article
- Correlation between Inflammasomes and Microbiota in Peri-Implantitis.International journal of molecular sciences · 2024Article
- Tumor-derived interleukin-1 receptor antagonist exhibits immunosuppressive functions and promotes pancreatic cancer.Cell & bioscience · 2023Article
- Immune response differences in degradable and non-degradable alloy implants.Bioactive materials · 2023Review
- Effects of NLRP3 on implants placement.Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2023Review
- The Role of Caspase-11 and Pyroptosis in the Regulation of Inflammation in Peri-Implantitis.Journal of inflammation research · 2023Review
- The role and mechanism of inflammatory response to growing rod implantation in early onset scoliosis.Frontiers in cell and developmental biology · 2023Review
- NLRP3 inflammasome activation in response to metals.Frontiers in immunology · 2023Review
- [Periodontitis Promotes the Progression of Oral Squamous Cell Carcinoma by Inducing Macrophage M2 Polarization].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2023Article
- Topography-mediated immunomodulation in osseointegration; Ally or Enemy.Biomaterials · 2022Review
- Ti Ions Induce IL-1β Release by Activation of the NLRP3 Inflammasome in a Human Macrophage Cell Line.Inflammation · 2022Article
- Nrf2 in the Field of Dentistry with Special Attention to NLRP3.Antioxidants (Basel, Switzerland) · 2022Review
- The progress in titanium alloys used as biomedical implants: From the view of reactive oxygen species.Frontiers in bioengineering and biotechnology · 2022Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Release of titanium ions (Ti ions) frequently occurs around dental implants and, as a consequence, higher content of Ti is typically present in peri-implantitis tissue. Unlike chronic periodontitis, Ti ions may play a role in the development of peri-implantitis. Inflammasomes are multiprotein signal transduction complexes, involved in inflammation and immune response, which lead to the secretion of mature cytokines associated with the progression of peri-implantitis. It is well known that T lymphocytes dominate the immune response in peri-implantitis, but whether Ti ions can impact the assembly of functional inflammasomes in T cells still remains unclear. Here, we observed that the mRNA expression of NLRP3 and CASP1, as well as the secretion of IL-1β, increased after 6-h incubation of Jurkat T cells with PHA and Ti ions. Moreover, measurement by confocal microscopy and flow cytometry assay indicates that Ti ions can promote the production of ROS, while NLRP3 expression and IL-1β secretion are reduced after treatment of Jurkat cells with NAC (ROS scavenger). Taken together, we presently show that Ti ions can activate NLRP3 inflammasome and then promote IL-β secretion in vitro, where ROS may play a mechanistic role in this activation process.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.