Evidence map›Paper›PMID 32103426›Full record

ReviewMolecular biotechnology2020

Engineering the Translational Machinery for Biotechnology Applications.

Tianwen Wang, Chen Liang, Yafei An, Sa Xiao, Hongjv Xu, Mengyuan Zheng, Lu Liu, Gaozhan Wang, Lei Nie

Abstract readReview
PubMed Publisher
In one paragraph

Review in Molecular biotechnology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Improvement of neutral protease activity ofJournal of Zhejiang University. Science. B · 2025
    Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Tianwen WangCollege of Life Sciences, and Institute for Conservation and Utilization of Agro-Bioresources in Dabie Mountains, Xinyang Normal University, Xinyang, 464000, China.ORCID http://orcid.org/0000-0001-7440-0056
Chen LiangCollege of Life Sciences, and Institute for Conservation and Utilization of Agro-Bioresources in Dabie Mountains, Xinyang Normal University, Xinyang, 464000, China.ORCID http://orcid.org/0000-0002-1552-2077
Yafei AnCollege of Life Sciences, and Institute for Conservation and Utilization of Agro-Bioresources in Dabie Mountains, Xinyang Normal University, Xinyang, 464000, China.ORCID http://orcid.org/0000-0002-0947-1891
Sa XiaoCollege of Life Sciences, and Institute for Conservation and Utilization of Agro-Bioresources in Dabie Mountains, Xinyang Normal University, Xinyang, 464000, China.ORCID http://orcid.org/0000-0002-7974-3979
Hongjv XuCollege of Life Sciences, and Institute for Conservation and Utilization of Agro-Bioresources in Dabie Mountains, Xinyang Normal University, Xinyang, 464000, China.ORCID http://orcid.org/0000-0002-9649-8012
Mengyuan ZhengCollege of Life Sciences, and Institute for Conservation and Utilization of Agro-Bioresources in Dabie Mountains, Xinyang Normal University, Xinyang, 464000, China.ORCID http://orcid.org/0000-0003-3535-8072
Lu LiuCollege of Life Sciences, and Institute for Conservation and Utilization of Agro-Bioresources in Dabie Mountains, Xinyang Normal University, Xinyang, 464000, China.ORCID http://orcid.org/0000-0001-8042-066X
Gaozhan WangCollege of Life Sciences, and Institute for Conservation and Utilization of Agro-Bioresources in Dabie Mountains, Xinyang Normal University, Xinyang, 464000, China.
Lei NieCollege of Life Sciences, and Institute for Conservation and Utilization of Agro-Bioresources in Dabie Mountains, Xinyang Normal University, Xinyang, 464000, China. nieleifu@yahoo.com.ORCID http://orcid.org/0000-0002-6175-5883

Funding

National Natural Science Foundation of China-Henan Joint Fund (CN) U180410
6 · The paper itself

Abstract

The ribosome is an essential organelle in charge of the translational processes in all kinds of cells. Currently, the scenario of its function has been significantly expanded from the classic machine for protein synthesis to a regulatory platform for quality control to maintain the protein homeostasis in a living cell. The ribosome is much more than a mechanical device with a static structure: it is inherently dynamic in structure and function, especially in response to the environmental fluctuations. Considerable effort has been made to regulate its structure and physiological function by engineering the components of a ribosome. The findings of the pioneering studies significantly deepened our understanding of a ribosome and exemplified how a ribosome could be engineered for biotechnology purposes in the era of synthetic biology. The engineering of ribosome offered highly accessible methods capable of comprehensively optimizing the performance of strains of industrial importance. In this article, the relevant recent advances were systematically reviewed.

Indexed as

Protein BiosynthesisAmino AcidsBiotechnologyCodon, NonsenseDrug Resistance, BacterialMetabolic EngineeringProtein EngineeringRibosomesRNA, CatalyticRNA, RibosomalRNA, TransferSynthetic BiologyAmino AcidsCodon, NonsenseRNA, CatalyticRNA, RibosomalRNA, TransferAntibiotic resistanceChemical modification of proteinNon-canonical amino acid incorporationOriented enzyme immobilizationRibosome engineeringSecondary metabolites

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.