Evidence map›Paper›PMID 32103343›Full record

ArticleActa neurochirurgica2020

A comparison of indirect and direct targeted STN DBS in the treatment of Parkinson's disease-surgical method and clinical outcome over 15-year timespan.

Maija Johanna Lahtinen, Tarja Helena Haapaniemi, Mikko Tapio Kauppinen, Niina Salokorpi, Esa Raimo Heikkinen, Jani Petteri Katisko

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta neurochirurgica, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.0field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Principles of Stereotactic Surgery.Operative neurosurgery (Hagerstown, Md.) · 2025
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Analysis of human brain tissue derived from DBS surgery.Translational neurodegeneration · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Maija Johanna LahtinenDepartment of Neurosurgery, Oulu University Hospital, Kajaanintie 50, FI-90220, Oulu, Finland. maija.lahtinen@ppshp.fi.
Tarja Helena HaapaniemiResearch Unit of Clinical Neuroscience, University of Oulu, Oulu, Finland.
Mikko Tapio KauppinenDepartment of Neurosurgery, Oulu University Hospital, Kajaanintie 50, FI-90220, Oulu, Finland.
Niina SalokorpiDepartment of Neurosurgery, Oulu University Hospital, Kajaanintie 50, FI-90220, Oulu, Finland.
Esa Raimo HeikkinenDepartment of Neurosurgery, Oulu University Hospital, Kajaanintie 50, FI-90220, Oulu, Finland.
Jani Petteri KatiskoDepartment of Neurosurgery, Oulu University Hospital, Kajaanintie 50, FI-90220, Oulu, Finland.
Oulu University Hospital · FIUniversity of Oulu · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDeep brain stimulation (DBS) in the subthalamic nucleus (STN) is used in advanced Parkinson's disease (PD) for reducing motor fluctuations and the side effects of antiparkinsonian medication (APM). The development of neuroimaging has enabled the direct targeting of the STN. The aim of this study is to evaluate the outcome in patients with PD using STN DBS when changing from atlas-based indirect targeting method (iTM) to direct MRI-based targeting (dTM) assuming dTM is superior.

methodsTwenty-five consecutive PD patients underwent dTM STN DBS surgery from 2014 to 2017 with follow-up for 1 year. The neuroimaging, surgical method, outcome in Unified Parkinson's Disease Rating Scale (UPDRS) scores, and reduction of APM are described and compared with the results of an earlier iTM STN DBS study.

resultsTwelve months after a dTM STN DBS, significant improvement (p < 0.001) was seen in six out of seven parameters of UPDRS when patients had medication (medON) and stimulation (stimON). The activities of daily living (UPDRSII) and motor scores (UPDRSIII) improved by 41% and 62%, respectively. Dyskinesias and fluctuations were both reduced by 81%. In dTM STN DBS group, the levodopa equivalent dose (LED) and the total daily levodopa equivalent dose (LEDD) were significantly decreased by 62% and 55%, respectively, compared with the baseline (p < 0.001). Five patients (20%) were without levodopa medication 12 months after the operation.

conclusionsThe development of surgical technique based on advanced neuroimaging has improved the outcome of PD STN DBS.

Indexed as

Activities of Daily LivingAgedAntiparkinson AgentsCombined Modality TherapyDeep Brain StimulationFemaleHumansLevodopaMagnetic Resonance ImagingMaleMiddle AgedParkinson DiseaseSubthalamic NucleusTreatment OutcomeAntiparkinson AgentsLevodopaDeep brain stimulationMagnetic resonance imagingParkinson’s diseaseSubthalamic nucleusTargeting

Identifiers

PMID32103343
PMCPMC7156355
OpenAlexW3007601778

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.