Evidence map›Paper›PMID 32103325›Full record

ArticleInternational journal of colorectal disease2020

Factors related to short-term outcomes and delayed systemic treatment following primary tumor resection for asymptomatic stage IV colorectal cancer.

Tetsuro Tominaga, Takashi Nonaka, Toshio Shiraisi, Kiyoaki Hamada, Keisuke Noda, Hiroaki Takeshita, Keizaburo Maruyama, Hidetoshi Fukuoka, Hideo Wada, Shintaro Hashimoto and 2 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in International journal of colorectal disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Efficacy of Primary Tumor Resection in Metastatic Colorectal Cancer.Medical science monitor : international medical journal of experimental and clinical research · 2020
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Tetsuro TominagaDepartments of Surgical Oncology, Nagasaki University Graduate School of Biomedical Science, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan. tetsuro.tominaga@nagasaki-u.ac.jp.ORCID http://orcid.org/0000-0001-9429-3227
Takashi NonakaDepartments of Surgical Oncology, Nagasaki University Graduate School of Biomedical Science, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan.
Toshio ShiraisiDepartment of Surgery, Sasebo City General Hospital, Sasebo, Japan.
Kiyoaki HamadaDepartment of Surgery, Sasebo City General Hospital, Sasebo, Japan.
Keisuke NodaDepartment of Surgery, Sasebo City General Hospital, Sasebo, Japan.
Hiroaki TakeshitaDepartment of Surgery, National Hospital Organization Nagasaki Medical Center, Ōmura, Japan.
Keizaburo MaruyamaDepartment of Surgery, Isahaya General Hospital, Isahaya, Japan.
Hidetoshi FukuokaDepartment of Surgery, Isahaya General Hospital, Isahaya, Japan.
Hideo WadaDepartment of Surgery, Ureshino Medical Center, Saga, Japan.
Shintaro HashimotoDepartment of Surgery, Saiseikai Nagasaki Hospital, Nagasaki, Japan.
Terumitsu SawaiDepartments of Surgical Oncology, Nagasaki University Graduate School of Biomedical Science, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan.
Takeshi NagayasuDepartments of Surgical Oncology, Nagasaki University Graduate School of Biomedical Science, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan.
Nagasaki University · JPSasebo City General Hospital · JPNagasaki Ajisai Hospital · JPNagasaki Medical Center · JPUreshino Medical Center · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe effectiveness of primary tumor resection (PTR) for asymptomatic stage IV colorectal cancer patients to continue prolonged and safe systemic chemotherapy has recently been re-evaluated. However, postoperative complications lead to a prolonged hospital stay and delay systemic treatment, which could result in a poor oncologic outcome. The objective of this study was to identify the risk factors for morbidity and delay of systemic chemotherapy in such patients.

methodsBetween April 2016 and March 2018, 115 consecutive colorectal cancer patients with distant metastasis who had no clinical symptoms and underwent PTR in all participating hospitals were retrospectively reviewed. The patients were divided into two groups according to the presence (CD ≥ 2, n = 23) or absence (CD < 2, n = 92) of postoperative complications.

resultsThe proportion of combined resection of adjacent organs was significantly higher in the postoperative complication group (p = 0.014). Complications were significantly correlated with longer hospital stay (p < 0.001) and delay of first postoperative treatment (p = 0.005). Univariate and multivariate analyses showed that combined resection (odds ratio 4.593, p = 0.010) was the independent predictor for postoperative complications. Median survival time was 8.5 months. Postoperative complications were not associated with overall survival, but four patients (3.5%) could not receive systemic chemotherapy because of prolonged postoperative complications.

conclusionsAlthough PTR for asymptomatic stage IV CRC patients showed an acceptable prognosis, appropriate patient selection is needed to obtain its true benefit.

Indexed as

AdultAgedAged, 80 and overColorectal NeoplasmsFemaleHumansMaleMiddle AgedNeoplasm MetastasisNeoplasm StagingPostoperative ComplicationsTime FactorsTreatment OutcomeColorectal cancerDistant metastasisPostoperative complicationPrimary tumor resection

Identifiers

PMID32103325
OpenAlexW3007754214

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.