Evidence map›Paper›PMID 32103279›Full record

ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2020

Chronic kidney disease-related osteoporosis is associated with incident frailty among patients with diabetic kidney disease: a propensity score-matched cohort study.

C-T Chao, J Wang, J-W Huang, D-C Chan, K-Y Hung, K-L Chien, COhort of GEriatric Nephrology in NTUH (COGENT) study group

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Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

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15citing papers in PubMed, 1 pooled it
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1 · What the graph read from it

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3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  12. Vascular frailty, a proposal for new frailty type: A narrative review.The Kaohsiung journal of medical sciences · 2023
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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

C-T ChaoDepartment of Internal Medicine, National Taiwan University Hospital BeiHu Branch, Taipei, Taiwan.
J WangInstitute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.
J-W HuangNephrology division, Department of Internal Medicine, National Taiwan University Hospital YunLin branch, Douliou, YunLin County, Taiwan. 007378@ntuh.gov.tw.ORCID http://orcid.org/0000-0003-2892-7986
D-C ChanDepartment of Internal Medicine, National Taiwan University Hospital ChuTung branch, Zhudong, HsinChu County, Taiwan.
K-Y HungDepartment of Internal Medicine, National Taiwan University Hospital HsinChu branch, HsinChu City, Taiwan.
K-L ChienInstitute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.
COhort of GEriatric Nephrology in NTUH (COGENT) study group

Funding

Ministry of Science and Technology, Taiwan MOST-108-2314-B-002-055-
6 · The paper itself

Abstract

Chronic kidney disease (CKD)-related osteoporosis is a major complication in patients with CKD, conferring a higher risk of adverse outcomes. We found that among those with diabetic kidney disease, this complication increased the risk of incident frailty, an important mediator of adverse outcomes.

introductionRenal osteodystrophy and chronic kidney disease (CKD)-related osteoporosis increases complications for patients with diabetic kidney disease (DKD). Since musculoskeletal degeneration is central to frailty development, we investigated the relationship between baseline osteoporosis and the subsequent frailty risk in patients with DKD.

methodsFrom the Longitudinal Cohort of Diabetes Patients in Taiwan (n = 840,000), we identified 12,027 patients having DKD with osteoporosis and 24,054 propensity score-matched controls having DKD but without osteoporosis. The primary endpoint was incident frailty on the basis of a modified FRAIL scale. Patients were prospectively followed-up until the development of endpoints or the end of this study. The Kaplan-Meier technique and Cox proportional hazard regression were used to analyze the association between osteoporosis at baseline and incident frailty in these patients.

resultsThe mean age of the DKD patients was 67.2 years, with 55.4% female and a 12.6% prevalence of osteoporosis at baseline. After 3.5 ± 2.2 years of follow up, the incidence rate of frailty in patients having DKD with osteoporosis was higher than that in DKD patients without (6.6 vs. 5.7 per 1000 patient-year, p = 0.04). A Cox proportional hazard regression showed that after accounting for age, gender, obesity, comorbidities, and medications, patients having DKD with osteoporosis had a significantly higher risk of developing frailty (hazard ratio, 1.19; 95% confidence interval, 1.02-1.38) than those without osteoporosis.

conclusionsCKD-related osteoporosis is associated with a higher risk of incident frailty in patients with DKD.

Indexed as

Diabetes MellitusDiabetic NephropathiesFrailtyOsteoporosisRenal Insufficiency, ChronicAgedAngiotensin-Converting Enzyme InhibitorsAngiotensin Receptor AntagonistsCohort StudiesFemaleHumansMalePropensity ScoreRisk FactorsTaiwanAngiotensin-Converting Enzyme InhibitorsAngiotensin Receptor AntagonistsChronic kidney diseaseChronic kidney disease-mineral bone disorderFractureFrail phenotypeFrailtyOsteoporosisRenal osteodystrophy

Identifiers

PMID32103279

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.