ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2021
Prevalence of Self-reported Neurologic and Ocular Symptoms in Early Syphilis Cases.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 21 citations in OpenAlex.
- Questions Ophthalmology Trainees Ask About Ocular Syphilis: A Question-Driven Narrative Review.Cureus · 2026Review
- Pathogens of the Human Central Nervous System- the Major Bacterial Pathogens.Molecular neurobiology · 2026Review
- Establishment of non-invasive diagnostic prediction model for HIV-positive asymptomatic neurosyphilis patients.BMC infectious diseases · 2025Article
- Syphilis and the Eye: Clinical Features, Diagnostic Challenges, and Evolving Therapeutic Paradigms.Pathogens (Basel, Switzerland) · 2025Review
- Latent class analysis and machine learning for clinical subtyping prediction and differentiation in suspected neurosyphilis patients.Frontiers in cellular and infection microbiology · 2025Article
- State-of-the-Art Review: Ocular Infections.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024Article
- Clinical Features of Syphilis Patients with Ocular Symptoms as the Initial Manifestation.Clinical ophthalmology (Auckland, N.Z.) · 2023Article
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- Papulosquamous eruption with ocular symptoms caused by syphilis.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2020Article
- Population and Individual-Level Effects of Human Immunodeficiency Virus Preexposure Prophylaxis on Sexually Transmitted Infection Epidemics Among Men Who Have Sex With Men.Sexually transmitted diseases · 2019Review
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Authors and funding
13 authors at 7 institutions in 1 country.
Funding
Abstract
backgroundNeurosyphilis, a complication of syphilis, can occur at any stage of infection. Measuring the prevalence of neurosyphilis is challenging, and there are limited data on the prevalence of neurologic or ocular symptoms among patients with syphilis. We sought to describe the prevalence of neurologic and/or ocular symptoms among early syphilis (ES) cases and the clinical management of symptomatic cases enrolled in the STD Surveillance Network (SSuN) Neuro/Ocular Syphilis Surveillance project.
methodsPersons diagnosed with ES were selected for interviews based on current health department protocols in 5 participating SSuN jurisdictions from November 2016 through October 2017. All interviewed ES cases were screened for self-reported neurologic and/or ocular symptoms. Additional clinical information on diagnostic testing and treatment for cases concerning for neurosyphilis/ocular syphilis was obtained from providers.
resultsAmong 9123 patients with ES who were interviewed, 151 (1.7%; 95% confidence interval [CI], 1.4%-1.9%) reported ≥ 1 neurologic or ocular symptom. Of the 53 (35%) who underwent lumbar puncture, 22 (42%) had documented abnormal cerebrospinal fluid, of which 21 (95%) were treated for neurosyphilis/ocular syphilis. Among the remaining 98 symptomatic patients with no documented lumbar puncture (65%), 12 (12%) were treated for and/or clinically diagnosed with neurosyphilis/ocular syphilis.
conclusionsWe observed a low prevalence of self-reported neurologic and/or ocular symptoms in interviewed ES cases. Approximately one-third of ES cases who self-reported symptoms underwent further recommended diagnostic evaluation. Understanding barriers to appropriate clinical evaluation is important to ensuring appropriate management of patients with possible neurologic and/or ocular manifestations of syphilis.
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