ArticleNature2020
Two conserved epigenetic regulators prevent healthy ageing.
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In one paragraph
Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.
0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed
5.8field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
66 citing papers in PubMed, 108 citations in OpenAlex.
- Whole-genome sequencing identifies genetic diversity and adaptive signatures of hypoxia and ultraviolet radiation in Chinese chickens.Journal of advanced research · 2026Article
- Loss of BCAP31 or POLR1E Accelerates Aging in C. elegans and is Linked to Senescence in Vascular Endothelium.Advanced biology · 2026Article
- Mitochondrial Enzymes Mimetic Ultrasmall Palladium Nanozymes Prevent Senescence and Neurodegeneration Through Metabolic Reprogramming.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Histone modification dynamics in brain aging: unlocking therapeutic potential.Cell death & disease · 2026Review
- Multi-tissue analysis identifies mitochondrial genes in chicken aging-induced productivity decline.Journal of animal science and biotechnology · 2026Article
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- Histone methyltransferase SET-18/SMYD2-mediated activation of NADase TIR-1d/SARM1 increases mtROS to promote aging.iScience · 2026Article
- Modifying Glucose Metabolism Reverses Memory Defects of Alzheimer's Disease Model at Late Stages.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- CDK3 induces neuronal death and brain atrophy in Alzheimer's disease.Nature aging · 2026Article
- Quo Vadis translational neuroscience?Translational neuroscience · 2026Review
- Multilayered regulation of longevity in Caenorhabditis elegans.Molecules and cells · 2026Review
- A gut-brain-gut axis orchestrates host responses counteracting microbiome-induced iron insufficiency.The EMBO journal · 2025Article
- LIMK1 Deficiency Disrupts Hippocampal-Cortical Memory Consolidation and Attenuates Trauma-Induced PTSD-like Behavior.Biology · 2025Article
- Unlocking biological insights from differentially expressed genes: Concepts, methods, and future perspectives.Journal of advanced research · 2025Review
- Dying occurs as a defined molecular progression iniScience · 2025Article
- mRNA translational control of regeneration.Current opinion in genetics & development · 2025Review
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- Targeting the chromatin remodeler BAZ2B mitigates hepatic senescence and MASH fibrosis.Nature aging · 2025Article
- A small-molecule screen identifies novel aging modulators by targeting 5-HT/DA signaling pathway.Aging cell · 2025Article
6 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
16 authors at 7 institutions in 1 country.
Jie Yuan *Institute of Neuroscience and State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China.
Si-Yuan Chang *Institute of Neuroscience and State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China.
Shi-Gang Yin *CAS Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China.
Zhi-Yang Liu *Institute of Neuroscience and State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China.
Xiu Cheng *CAS Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China.
Xi-Juan LiuInstitute of Neuroscience and State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China.
Qiang JiangInstitute of Neuroscience and State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China.
Ge GaoInstitute of Neuroscience and State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China.
De-Ying LinInstitute of Neuroscience and State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China.
Xin-Lei KangInstitute of Neuroscience and State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China.
Shi-Wei YeInstitute of Neuroscience and State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China.
Zheng ChenCollege of Biological and Environmental Sciences, Zhejiang Wanli University, Ningbo, China.
Jiang-An YinInstitute of Neuroscience and State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China.
Pei HaoCAS Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China.
Lubin JiangCAS Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China. lbjiang@ips.ac.cn.
Shi-Qing CaiInstitute of Neuroscience and State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China. sqcai@ion.ac.cn.
Chinese Academy of Sciences · CNCenter for Excellence in Brain Science and Intelligence Technology · CNUniversity of Chinese Academy of Sciences · CNAffiliated Hospital of Southwest Medical University · CNInstitut Pasteur of Shanghai · CNShanghai Center for Brain Science and Brain-Inspired Technology · CNZhejiang Wanli University · CN
Funding
No grant is acknowledged in the PubMed record.
Abstract
It has long been assumed that lifespan and healthspan correlate strongly, yet the two can be clearly dissociated
Indexed as
Epigenesis, GeneticAgingAnimalsBromodomain Containing ProteinsCaenorhabditis elegansCaenorhabditis elegans ProteinsCognitionCognitive DysfunctionHealthy AgingHistone-Lysine N-MethyltransferaseHistonesHumansLongevityLysineMaleMemoryBAZ2B protein, humanBaz2b protein, mouseBAZ-2 protein, C elegansBromodomain Containing ProteinsCaenorhabditis elegans ProteinsEHMT1 protein, humanHistone-Lysine N-MethyltransferaseHistonesLysineProteinsSET-6 protein, C elegansTranscription Factors, General
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.