ArticleNature2020
Lipid availability determines fate of skeletal progenitor cells via SOX9.
Open access · greenAbstract read
In one paragraph
Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 156 papers.
0numbers the graph read from it
0cells of the map it votes in
156citing papers in PubMed
10.2field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
156 citing papers in PubMed, 224 citations in OpenAlex.
- Tetrahedral framework nucleic acids: Nanokeys unlocking a new era of precision biomedicine.Journal of advanced research · 2026Review
- Obesity-induced oleic acid metabolic dysregulation may exacerbate osteoarthritis through the degradation of SOX9.Cellular and molecular life sciences : CMLS · 2026Article
- Palmitic Acid Alters Longitudinal Bone Growth While Enhancing Matrix Maturation in an Organotypic Bone Model.Biomolecules · 2026Article
- Phospholipid Networks as Metabolic Hubs and Signaling Integrators in Plant Development and Stress Adaptation.Plants (Basel, Switzerland) · 2026Review
- Bioinspired, Mitochondria-Targeted Single-Atom Nanozyme Enhances Bone Regeneration by Reprogramming Stem Cell Energy Metabolism.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Sulfated polysaccharide reprograms arterialized angiogenesis of endochondral ossification to rescue defective osteonecrosis therapy.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- CAP-CD56Bioactive materials · 2026Article
- Changes in bone characteristics precede serum mineral deterioration in a mouse model of early stage chronic kidney disease.JBMR plus · 2026Article
- Fibrous-layer resident Angptl7Cell research · 2026Article
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- A bio-adaptive physical hydrogel enables dynamic tissue engineering for tracheal reconstruction.Nature communications · 2025Article
- A self-assembled nano micelle-exosome with high selectivity and penetrability achieves precise intracartilage lipid delivery.Science advances · 2025Article
- Delivery of miR-29a/29c-3p by serum exosomes promotes osteogenesis through TET3-dependent Sox9 demethylation and PI3K/Akt activation.Journal of nanobiotechnology · 2025Article
- Directed rescue strategy for enhanced implant osteointegration in aged rats.Nature communications · 2025Article
- Mesenchymal stem cells and extracellular vesicles for knee osteoarthritis: clinical application, mechanism exploration and prospect.Stem cell research & therapy · 2025Review
- Erythroid precursors regulate local oxygen tension and repair outcomes in the bone marrow niche.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Association of triglycerides with bone mineral density in children and adolescents: a cross-sectional study.BMC musculoskeletal disorders · 2025Article
- The Periosteum in Health and Disease.Current osteoporosis reports · 2025Review
- Developmental low-dose bisphenol A exposure leads to extensive transcriptome female masculinization and male feminization later in life.Communications medicine · 2025Article
96 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
24 authors at 6 institutions in 4 countries.
Nick van GastelLaboratory of Clinical and Experimental Endocrinology, Department of Chronic Diseases, Metabolism and Ageing, KU Leuven, Leuven, Belgium.
Steve StegenLaboratory of Clinical and Experimental Endocrinology, Department of Chronic Diseases, Metabolism and Ageing, KU Leuven, Leuven, Belgium.
Guy EelenLaboratory of Angiogenesis and Vascular Metabolism, Department of Oncology, KU Leuven, Leuven, Belgium.
Sandra SchoorsLaboratory of Angiogenesis and Vascular Metabolism, Department of Oncology, KU Leuven, Leuven, Belgium.
Aurélie CarlierPrometheus, Division of Skeletal Tissue Engineering, KU Leuven, Leuven, Belgium.
Veerle W DaniëlsLaboratory of Lipid Metabolism and Cancer, Department of Oncology, KU Leuven, Leuven, Belgium.
Ninib BaryawnoDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.
Dariusz PrzybylskiHoward Hughes Medical Institute and Department of Biology, Brandeis University, Waltham, MA, USA.
Maarten DepypereMedical Imaging Research Center, KU Leuven, Leuven, Belgium.
Pieter-Jan StiersLaboratory of Clinical and Experimental Endocrinology, Department of Chronic Diseases, Metabolism and Ageing, KU Leuven, Leuven, Belgium.
Dennis LambrechtsPrometheus, Division of Skeletal Tissue Engineering, KU Leuven, Leuven, Belgium.
Riet Van LooverenLaboratory of Clinical and Experimental Endocrinology, Department of Chronic Diseases, Metabolism and Ageing, KU Leuven, Leuven, Belgium.
Sophie TorrekensLaboratory of Clinical and Experimental Endocrinology, Department of Chronic Diseases, Metabolism and Ageing, KU Leuven, Leuven, Belgium.
Azeem ShardaDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.
Patrizia AgostinisLaboratory of Cell Death Research and Therapy, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium.
Diether LambrechtsLaboratory of Translational Genetics and Laboratory for Functional Epigenetics, Department of Human Genetics, KU Leuven, Leuven, Belgium.
Frederik MaesMedical Imaging Research Center, KU Leuven, Leuven, Belgium.
Johan V SwinnenLaboratory of Lipid Metabolism and Cancer, Department of Oncology, KU Leuven, Leuven, Belgium.
Liesbet GerisPrometheus, Division of Skeletal Tissue Engineering, KU Leuven, Leuven, Belgium.
Hans Van OosterwyckPrometheus, Division of Skeletal Tissue Engineering, KU Leuven, Leuven, Belgium.
Bernard ThienpontLaboratory of Translational Genetics and Laboratory for Functional Epigenetics, Department of Human Genetics, KU Leuven, Leuven, Belgium.
Peter CarmelietLaboratory of Angiogenesis and Vascular Metabolism, Department of Oncology, KU Leuven, Leuven, Belgium.
David T ScaddenDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.
Geert CarmelietLaboratory of Clinical and Experimental Endocrinology, Department of Chronic Diseases, Metabolism and Ageing, KU Leuven, Leuven, Belgium. geert.carmeliet@kuleuven.be.
KU Leuven · BEVIB-KU Leuven Center for Cancer Biology · BEHarvard University · USHarvard Stem Cell Institute · USHoward Hughes Medical Institute · USUniversity of Liège · BE
Funding
Transcriptional and epigenetic heterogeneity of stem/progenitor cellsP01HL131477 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI DANIEL G TENEN · 2017 to 2026
$24.6MEuropean Research Council 279100European Research Council 308223NHLBI NIH HHS P01 HL131477
Abstract
The avascular nature of cartilage makes it a unique tissue
Indexed as
Cellular MicroenvironmentChondrogenesisLipid MetabolismAnimalsBone and BonesChondrocytesFatty AcidsFemaleFood DeprivationForkhead Transcription FactorsMaleMiceMice, Inbred C57BLOsteogenesisOxidation-ReductionSignal TransductionFatty AcidsForkhead Transcription FactorsSox9 protein, mouseSOX9 Transcription Factor
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.