ArticleNature2020
Global chemical effects of the microbiome include new bile-acid conjugations.
Open access · greenAbstract read
In one paragraph
Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 373 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
373citing papers in PubMed, 2 pooled it
25.3field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
373 citing papers in PubMed, 2 syntheses or guidelines pooled it, 571 citations in OpenAlex.
- IBD-related inflammatory memory and colorectal cancer: epigenetic mechanisms and microbiome interventions.Frontiers in immunology · 2026Pooled it
- Meta-analysis of the human gut microbiome uncovers shared and distinct microbial signatures between diseases.mSystems · 2024Pooled it
- Host diets drive microbiome evolution and functional divergence.Genes & diseases · 2027Review
- The gut microbiome and mitochondrial function in metabolism, immunity, and disease.Gut microbes · 2026Review
- The gut microbiome-bile acid-FXR interplay: a pivotal axis in metabolic and gastrointestinal diseases.Gut microbes · 2026Review
- A bile acid-GPBAR1 network supports anti-inflammatory and anti-fibrotic benefits of probiotics in colitis.Gut microbes · 2026Article
- Evaluation of the substrate profile of microbial-host-isozyme reveals the role of BvDPP4 in inflammatory bowel disease.Science China. Life sciences · 2026Article
- Pleiotropic roles of microbial bile acid metabolism in intestinal health and diseases.Cell host & microbe · 2026Review
- Bile acid signaling in health and disease.Molecular biomedicine · 2026Review
- Expanding bile acid diversityNatural product reports · 2026Review
- Article
- Bile Acid Metabolism as a Unifying Readout for Diet, Microbiome Function, and Gastrointestinal Disease.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Review
- The urinary pathobiont Actinobaculum massiliense can generate androgens via the dirAB pathway.Nature communications · 2026Article
- Xenobiotic transfer of onabotulinumtoxinA using an ex vivo human placental perfusion model: A pilot study.Pregnancy (Hoboken, N.J.) · 2026Article
- Review
- Ordering molecular diversity in untargeted metabolomics via molecular community networking.Cell reports methods · 2026Article
- The microbiome regulates host metabolic health and diseases through microbial enzymes.Nature reviews. Gastroenterology & hepatology · 2026Review
- The human microbiome as a source of novel bioactive natural products: structures, bioactivities, and biosynthetic insights.Journal of natural medicines · 2026Review
- Mass spectrometry-based metabolomics approaches to interrogate host-microbiome interactions in mammalian systems.Natural product reports · 2026Review
- Multi-omics profiling and bile-acid exposure assays implicate a gut microbiome-parasite axis linked to persistent Entamoeba histolytica carriage.Gut pathogens · 2026Article
313 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
58 authors at 10 institutions in 1 country.
Robert A QuinnCollaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, San Diego, CA, USA.
Alexey V MelnikCollaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, San Diego, CA, USA.
Alison VrbanacDepartment of Pediatrics, University of California San Diego, San Diego, CA, USA.
Ting FuGene Expression Laboratory, Salk Institute for Biological Studies, San Diego, CA, USA.
Kathryn A PatrasDepartment of Pediatrics, University of California San Diego, San Diego, CA, USA.
Mitchell P ChristyCollaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, San Diego, CA, USA.
Zsolt BodaiDepartment of Chemistry and Biochemistry, University of California San Diego, San Diego, CA, USA.
Pedro Belda-FerreDepartment of Pediatrics, University of California San Diego, San Diego, CA, USA.
Anupriya TripathiCollaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, San Diego, CA, USA.
Lawton K ChungDepartment of Pediatrics, University of California San Diego, San Diego, CA, USA.
Michael DownesGene Expression Laboratory, Salk Institute for Biological Studies, San Diego, CA, USA.
Ryan D WelchGene Expression Laboratory, Salk Institute for Biological Studies, San Diego, CA, USA.
Melissa QuinnDepartment of Kinesiology, Michigan State University, East Lansing, MI, USA.
Greg HumphreyDepartment of Pediatrics, University of California San Diego, San Diego, CA, USA.
Morgan PanitchpakdiCollaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, San Diego, CA, USA.
Kelly C WeldonCollaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, San Diego, CA, USA.
Alexander AksenovCollaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, San Diego, CA, USA.
Ricardo da SilvaCollaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, San Diego, CA, USA.
Julian Avila-PachecoBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Clary ClishBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Sena BaeDepartment of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
Himel MallickBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Eric A FranzosaBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Jason Lloyd-PriceBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Robert BussellDepartment of Radiology, University of California San Diego, San Diego, CA, USA.
Taren ThronDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Andrew T NelsonCollaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, San Diego, CA, USA.
Mingxun WangCollaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, San Diego, CA, USA.
Eric LeszczynskiDepartment of Kinesiology, Michigan State University, East Lansing, MI, USA.
Fernando VargasCollaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, San Diego, CA, USA.
Julia M GauglitzCollaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, San Diego, CA, USA.
Michael J MeehanCollaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, San Diego, CA, USA.
Emily GentryCollaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, San Diego, CA, USA.
Timothy D ArthurDepartment of Pediatrics, University of California San Diego, San Diego, CA, USA.
Alexis C KomorDepartment of Chemistry and Biochemistry, University of California San Diego, San Diego, CA, USA.
Orit PoulsenDepartment of Pediatrics, University of California San Diego, San Diego, CA, USA.
Brigid S BolandDivision of Gastroenterology, Department of Medicine, University of California San Diego, San Diego, CA, USA.
John T ChangDivision of Gastroenterology, Department of Medicine, University of California San Diego, San Diego, CA, USA.
William J SandbornDivision of Gastroenterology, Department of Medicine, University of California San Diego, San Diego, CA, USA.
Meerana LimDepartment of Pediatrics, University of California San Diego, San Diego, CA, USA.
Neha GargSchool of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA, USA.
Julie C LumengDepartment of Pediatrics, University of Michigan, Ann Arbor, MI, USA.
Ramnik J XavierBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Barbara I KazmierczakDepartment of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.
Ruchi JainDepartment of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.
Marie EganDepartment of Pediatrics, Yale School of Medicine, New Haven, CT, USA.
Kyung E RheeDepartment of Pediatrics, University of California San Diego, San Diego, CA, USA.
David FergusonDepartment of Kinesiology, Michigan State University, East Lansing, MI, USA.
Manuela RaffatelluDepartment of Pediatrics, University of California San Diego, San Diego, CA, USA.
Hera VlamakisBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Gabriel G HaddadDepartment of Pediatrics, University of California San Diego, San Diego, CA, USA.
Dionicio SiegelCollaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, San Diego, CA, USA.
Curtis HuttenhowerBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Sarkis K MazmanianDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Ronald M EvansGene Expression Laboratory, Salk Institute for Biological Studies, San Diego, CA, USA.
Victor NizetCollaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, San Diego, CA, USA.
Rob KnightDepartment of Pediatrics, University of California San Diego, San Diego, CA, USA.
Pieter C DorresteinCollaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, San Diego, CA, USA. pdorrestein@ucsd.edu.
University of California, San Diego · USBroad Institute · USUniversity of Montana · USSalk Institute for Biological Studies · USMichigan State University · USYale University · USCalifornia Institute of Technology · USCystic Fibrosis Foundation · USHarvard University · USUniversity of Michigan–Ann Arbor · US
Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MViral Vector Core (VVC)P30CA014195 · NCI · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI Ye Zheng · 1985 to 2026
$82.8MYeast Genetics and Stress Response Genes-BiomedicalP42ES010337 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TUKEY, ROBERT H · 2000 to 2022
$69.8MPilot & Feasibility ProgramP30DK043351 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI RAYMOND T CHUNG · 1991 to 2026
$35.3MROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI CHRISTOPHER P DUGGAN · 1994 to 2026
$31.6MTranscriptional GenomicsP01HL088093 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MILLER, YURY · 2008 to 2018
$26.4MHORMONAL REGULATION OF MAMMALIAN GENE EXPRESSIONR37DK057978 · NIDDK · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI EVANS, RONALD M · 2000 to 2019
$16.0MUC San Diego Clinical and Translational Research InstituteKL2TR001444 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DEPP, COLIN A. · 2015 to 2024
$15.4MSan Diego Digestive Diseases Research CenterP30DK120515 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LARS ECKMANN, Bernd G. Schnabl · 2019 to 2026
$10.8MSystems Biology Approach to Redefine Susceptibility Testing and Treatment of MDR Pathogens in the Context of Host ImmunityU01AI124316 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PALSSON, BERNHARD O · 2016 to 2020
$10.2MSan Diego Biomedical Informatics Education & Research (SABER)T15LM011271 · NLM · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SHAMIM NEMATI · 2012 to 2026
$9.7MUnified Computation Tools for Natural Products ResearchR01GM107550 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI COTTRELL, GARRISON W, GERWICK, WILLIAM HENRY · 2013 to 2025
$8.2MHoward Hughes Medical InstituteNCATS NIH HHS KL2 TR001444NCATS NIH HHS UL1 TR001863NCCIH NIH HHS DP1 AT010885NCI NIH HHS CA014195NCI NIH HHS P30 CA014195NCI NIH HHS R03 CA211211NCRR NIH HHS S10 RR029121NHLBI NIH HHS P01 HL088093NHLBI NIH HHS R01 HL105278NHLBI NIH HHS R01 HL116235NIAID NIH HHS R01 AI126277NIAID NIH HHS U01 AI124316NICHD NIH HHS R01 HD084163NIDCR NIH HHS U54 DE023798NIDDK NIH HHS P30 DK040561NIDDK NIH HHS P30 DK043351NIDDK NIH HHS P30 DK120515NIDDK NIH HHS R01 DK057978NIDDK NIH HHS R24 DK110499NIDDK NIH HHS R37 DK057978NIDDK NIH HHS T32 DK007494NIEHS NIH HHS P42 ES010337NIGMS NIH HHS R01 GM107550NIH HHS 1 DP1 AT010885NIH HHS 1R01HL116235NIH HHS 1R03CA211211-01NIH HHS 5U01AI124316-03NIH HHS GMS10RR029121NIH HHS R24DK110499NIH HHS U54DE023798NLM NIH HHS T15 LM011271
Abstract
A mosaic of cross-phylum chemical interactions occurs between all metazoans and their microbiomes. A number of molecular families that are known to be produced by the microbiome have a marked effect on the balance between health and disease
Indexed as
MetabolomicsAnimalsBile Acids and SaltsCholic AcidCystic FibrosisGerm-Free LifeHumansInflammatory Bowel DiseasesMiceMicrobiotaReceptor, Farnesoid X-ActivatedReceptors, Cytoplasmic and NuclearBile Acids and SaltsCholic AcidReceptor, Farnesoid X-ActivatedReceptors, Cytoplasmic and Nuclear
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.