ArticleNature2020
DNA-PKcs has KU-dependent function in rRNA processing and haematopoiesis.
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In one paragraph
Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.
0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed
5.1field-weighted citation impact, top 3% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
68 citing papers in PubMed, 96 citations in OpenAlex.
- Programmed Clonal Expansion Associated with V(D)J Recombination Drives an ATM-Dependent Vulnerability Underlying Preferential Lymphocyte Depletion and Myeloid Bias Following DNA Damage.bioRxiv : the preprint server for biology · 2026Article
- Nuclear localization of the glutaminyl-tRNA synthetase QARS reveals its role in DNA damage response in ovarian cancer.Nature communications · 2026Article
- Review
- Ku70-SAP domain has an overlapping function with DNA-PKcs in limiting the lateral movement of the Ku ring along DNA.Nucleic acids research · 2026Article
- Discovery of an Endonuclease G-inhibitory Ku80-peptide protecting against leukemogenic rearrangements at the MLL breakpoint cluster.Nature communications · 2026Article
- Nonhomologous end joining-the importance of end tethering and beyond.Genes & development · 2026Review
- Review
- Dysregulation of the DNA damage response by phosphorothioate antisense oligonucleotides.Nature communications · 2026Article
- Visualization and quantification of rDNA instabilities in mammalian cells and mouse models.Nucleic acids research · 2026Article
- Single-cell multiplex approaches deeply map ON-target CRISPR-genotoxicity and reveal its mitigation by palbociclib and long-term engraftment.Nature communications · 2026Article
- Primate-specific adaptation of Ku protects transcriptomic integrity by suppressing Alu-mediated alternative splicing.bioRxiv : the preprint server for biology · 2025Article
- Ku limits aberrant mRNA splicing promoted by intronic antisense Alu elements.bioRxiv : the preprint server for biology · 2025Article
- Non-Coding RNAs in Asthma: Regulators of Eosinophil Biology and Airway Inflammation.Diagnostics (Basel, Switzerland) · 2025Review
- Article
- Article
- Article
- NBS1 facilitates preribosomal RNA biogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- DNA-PKcs, a player winding and dancing with RNA metabolism and diseases.Cellular & molecular biology letters · 2025Review
- Nucleolar NOL9 regulated by DNA methylation promotes hepatocellular carcinoma growth through activation of Wnt/β-catenin signaling pathway.Cell death & disease · 2025Article
- EFTUD2 is a promising diagnostic and prognostic indicator involved in the tumor immune microenvironment and glycolysis of lung adenocarcinoma.Frontiers in oncology · 2025Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
14 authors at 4 institutions in 1 country.
Zhengping Shao *Institute for Cancer Genetics, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Ryan A Flynn *Department of Chemistry, Stanford University, Stanford, CA, USA.
Jennifer L Crowe *Institute for Cancer Genetics, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Yimeng Zhu *Institute for Cancer Genetics, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Jialiang LiangDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.
Wenxia JiangInstitute for Cancer Genetics, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Fardin AryanDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.
Patrick AoudeDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.
Carolyn R BertozziDepartment of Chemistry, Stanford University, Stanford, CA, USA.
Verna M EstesInstitute for Cancer Genetics, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Brian J LeeInstitute for Cancer Genetics, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Govind BhagatHerbert Irving Comprehensive Cancer Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Shan ZhaInstitute for Cancer Genetics, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA. sz2296@columbia.edu.
Eliezer CaloDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA. calo@mit.edu.
Cancer Genetics (United States) · USColumbia University · USMassachusetts Institute of Technology · USStanford University · US
Funding
Tumor Biology and Microenvironment ProgramP30CA013696 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Parisa Tehranifar · 1985 to 2026
$115.3MThe role of ATM in the suppression of lymphoid malignancyR01CA158073 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Shan Zha · 2011 to 2026
$5.7MThe structural function of ATR in development, oncogenesis and cancer therapyR01CA215067 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ZHA, SHAN · 2017 to 2021
$1.9MDNA-PKCS Phosphorylation in DNA Repair and Chromosomal TranslocationsR01CA184187 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ZHA, SHAN · 2015 to 2019
$1.8MNon-catalytic functions of DNA-PK in DNA repair and tumorigenesisF31CA183504 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CROWE, JENNIFER L · 2014 to 2016
$129kNCI NIH HHS F31 CA183504NCI NIH HHS P30 CA013696NCI NIH HHS R01 CA158073NCI NIH HHS R01 CA184187NCI NIH HHS R01 CA215067
Abstract
The DNA-dependent protein kinase (DNA-PK), which comprises the KU heterodimer and a catalytic subunit (DNA-PKcs), is a classical non-homologous end-joining (cNHEJ) factor
Indexed as
Calcium-Binding ProteinsCatalytic DomainDNA RepairEnzyme ActivationHeLa CellsHematopoiesisHumansKu AutoantigenLymphomaModels, AnimalMutationPhosphorylationProtein BindingProtein BiosynthesisRNA, Ribosomal, 18SRNA, Small NucleolarCalcium-Binding ProteinsCIB1 protein, humanKu AutoantigenRNA, Ribosomal, 18SRNA, Small NucleolarRNA, U3 small nucleolar
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.