Evidence map›Paper›PMID 32103153›Full record

ArticleMucosal immunology2020

Thymic stromal lymphopoietin protects in a model of airway damage and inflammation via regulation of caspase-1 activity and apoptosis inhibition.

Nicholas J Shubin, Morgan Clauson, Kerri Niino, Victoria Kasprzak, Avery Tsuha, Eric Guga, Gauri Bhise, Manasa Acharya, Jessica M Snyder, Jason S Debley and 2 more

Open access · hybridAbstract read
In one paragraph

Article in Mucosal immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Review
  11. Article
  12. Review
  13. Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Nicholas J ShubinCenter for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, WA, 98101, USA.
Morgan ClausonCenter for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, WA, 98101, USA.
Kerri NiinoCenter for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, WA, 98101, USA.
Victoria KasprzakCenter for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, WA, 98101, USA.
Avery TsuhaCenter for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, WA, 98101, USA.
Eric GugaCenter for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, WA, 98101, USA.
Gauri BhiseCenter for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, WA, 98101, USA.
Manasa AcharyaCenter for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, WA, 98101, USA.
Jessica M SnyderDepartment of Comparative Medicine, School of Medicine, University of Washington, Seattle, WA, 98195, USA.
Jason S DebleyCenter for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, WA, 98101, USA.
Steven F ZieglerImmunology Program, Benaroya Research Institute at Virginia Mason, Seattle, WA, 98101, USA.
Adrian M PiliponskyCenter for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, WA, 98101, USA. adrian.piliponsky@seattlechildrens.org.
University of Washington · USSeattle Children's Hospital · USVirginia Mason Medical Center · US

Funding

Thymic Stromal Lymphopoietin (TSLP) and Lung Inflammation and ImmP01HL098067 · NHLBI · BENAROYA RESEARCH INST AT VIRGINIA MASON · PI WIGHT, THOMAS N · 2010 to 2014
$13.5M
TSLP and the Pathophysiology of AsthmaR01AI068731 · NIAID · BENAROYA RESEARCH INST AT VIRGINIA MASON · PI ZIEGLER, STEVEN F · 2006 to 2016
$4.5M
Regulation of TSLP receptor expression and function in eczema in mice and manR01AR059058 · NIAMS · UNIVERSITY OF VIRGINIA · PI WOODFOLK, JUDITH A, ZIEGLER, STEVEN F · 2011 to 2015
$2.7M
Critical role of chymase in the regulation of inflammation and survival in sepsisR01HL113351 · NHLBI · SEATTLE CHILDREN'S HOSPITAL · PI PILIPONSKY, ADRIAN M · 2012 to 2016
$2.4M
Dysregulated Airway Epithelial Signaling as a Driver of Airway Remodeling in Asthmatic ChildrenR01HL128361 · NHLBI · SEATTLE CHILDREN'S HOSPITAL · PI DEBLEY, JASON S · 2016 to 2018
$1.4M
Impact of Heterogeneous Airway Epithelial ACE2 Expression and Interferon Responses on SARS-CoV2 Infectivity and ReplicationK24AI150991 · NIAID · SEATTLE CHILDREN'S HOSPITAL · PI DEBLEY, JASON S · 2020 to 2024
$1.2M
Dysregulated Airway Epithelial Signaling as a Driver of Airway Remodeling in Asthmatic ChildrenR56HL128361 · NHLBI · SEATTLE CHILDREN'S HOSPITAL · PI DEBLEY, JASON S · 2015 to 2015
$483k
NHLBI NIH HHS P01 HL098067NHLBI NIH HHS R01 HL113351NHLBI NIH HHS R01 HL128361NHLBI NIH HHS R56 HL128361NIAID NIH HHS K24 AI150991NIAID NIH HHS R01 AI068731NIAMS NIH HHS R01 AR059058
6 · The paper itself

Abstract

Thymic stromal lymphopoietin (TSLP), an epithelial cell-derived cytokine, exhibits both pro-inflammatory and pro-homeostatic properties depending on the context and tissues in which it is expressed. It remains unknown whether TSLP has a similar dual role in the airways, where TSLP is known to promote allergic inflammation. Here we show that TSLP receptor (TSLPR)-deficient mice (Tslpr

Indexed as

AnimalsApoptosisbcl-X ProteinBiomarkersBleomycinCaspase 1Caspase 3CytokinesDisease Models, AnimalDisease SusceptibilityEpithelial CellsHumansImmunoglobulinsImmunohistochemistryInflammationMicebcl-X ProteinBiomarkersBleomycinCaspase 1Caspase 3CytokinesImmunoglobulinsProtective AgentsReceptors, CytokineThymic Stromal LymphopoietinTslpr protein, mouse

Identifiers

PMID32103153
PMCPMC7312418
OpenAlexW3008750681

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.