ArticleScientific reports2020
Primary functional brain connections associated with melancholic major depressive disorder and modulation by antidepressants.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 39 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 2 syntheses or guidelines pooled it, 72 citations in OpenAlex.
- Melancholic features (DSM-IV) predict but do not moderate response to antidepressants in major depression: an individual participant data meta-analysis of 1219 patients.European archives of psychiatry and clinical neuroscience · 2021Pooled it
- Resting State Functional Connectivity of Brain With Electroconvulsive Therapy in Depression: Meta-Analysis to Understand Its Mechanisms.Frontiers in human neuroscience · 2020Pooled it
- Enhancement of the left frontoparietal network through real-time functional magnetic resonance imaging functional connectivity-informed neurofeedback and its impact on working memory in schizophrenia: A pilot study.Psychiatry and clinical neurosciences · 2025Trial
- Identification of abnormal neural language networks by reading "brainprints" in patients with brain tumors.Neuroimage. Reports · 2026Article
- Paving the way for precision treatment of psychiatric symptoms with functional connectivity neurofeedback.Translational psychiatry · 2026Article
- Inferring relationships among major psychiatric disorders in a resting-state functional connectivity-informed embedding space.NPJ systems biology and applications · 2026Article
- Severity-dependent fronto-cingulate network compensation of immune-dependent caudate-insula dysconnectivity in bipolar II depression.Research square · 2026Article
- Generalizable stratification based on thalamo-somatomotor functional connectivity predicts responses to antidepressants in patients with depression.Molecular psychiatry · 2026Article
- Global and item-level MADRS differences between melancholic and unspecified depressive symptoms under rTMS: an exploratory analysis.Frontiers in psychiatry · 2026Article
- Prefronto-thalamic hypoconnectivity in schizophrenia: Monkey to human translation of critical pathways for symptom-related functions.PCN reports : psychiatry and clinical neurosciences · 2025Article
- Computational mechanisms of neuroimaging biomarkers uncovered by multicenter resting-state fMRI connectivity variation profile.Molecular psychiatry · 2025Article
- Random Walk-Based Node Feature Learning for Major Depressive Disorder Identification Through Multi-Site rs-fMRI Data.Human brain mapping · 2025Article
- Degree centrality values in the left calcarine as a potential imaging biomarker for anxious major depressive disorder.World journal of psychiatry · 2025Article
- Generalizable and transportable resting-state neural signatures characterized by functional networks, neurotransmitters, and clinical symptoms in autism.Molecular psychiatry · 2025Article
- Advancing the diagnosis of major depressive disorder: Integrating neuroimaging and machine learning.World journal of psychiatry · 2025Article
- The status of MRI databases across the world focused on psychiatric and neurological disorders.Psychiatry and clinical neurosciences · 2024Review
- Dimensional and Categorical Solutions to Parsing Depression Heterogeneity in a Large Single-Site Sample.Biological psychiatry · 2024Article
- Depression Severity, Slow- versus Fast-Wave Neural Activity, and Symptoms of Melancholia.Brain sciences · 2024Article
- Trait repetitive negative thinking in depression is associated with functional connectivity in negative thinking state rather than resting state.Journal of affective disorders · 2023Article
- Trait repetitive negative thinking in depression is associated with functional connectivity in negative thinking state rather than resting state.bioRxiv : the preprint server for biology · 2023Article
Corrections and comments
- Erratum issued
Authors and funding
20 authors at 9 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The limited efficacy of available antidepressant therapies may be due to how they affect the underlying brain network. The purpose of this study was to develop a melancholic MDD biomarker to identify critically important functional connections (FCs), and explore their association to treatments. Resting state fMRI data of 130 individuals (65 melancholic major depressive disorder (MDD) patients, 65 healthy controls) were included to build a melancholic MDD classifier, and 10 FCs were selected by our sparse machine learning algorithm. This biomarker generalized to a drug-free independent cohort of melancholic MDD, and did not generalize to other MDD subtypes or other psychiatric disorders. Moreover, we found that antidepressants had a heterogeneous effect on the identified FCs of 25 melancholic MDDs. In particular, it did impact the FC between left dorsolateral prefrontal cortex (DLPFC)/inferior frontal gyrus (IFG) and posterior cingulate cortex (PCC)/precuneus, ranked as the second 'most important' FC based on the biomarker weights, whilst other eight FCs were normalized. Given that left DLPFC has been proposed as an explicit target of depression treatments, this suggest that the limited efficacy of antidepressants might be compensated by combining therapies with targeted treatment as an optimized approach in the future.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.