ArticleScientific reports2020
A system-level mechanistic explanation for asymmetric stem cell fates: Arabidopsis thaliana root niche as a study system.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Cellular patterns in Arabidopsis root epidermis emerge from gene regulatory network and diffusion dynamical feedback.NPJ systems biology and applications · 2025Article
- How meristems shape plant architecture in cereals-Cereal Stem Cell Systems (CSCS) Consortium.The Plant cell · 2025Review
- Computational modeling of plant root development: the art and the science.The New phytologist · 2025Review
- Refining Boolean models with the partial most permissive scheme.Bioinformatics (Oxford, England) · 2025Article
- The MADS-box gene XAANTAL1 participates in Arabidopsis thaliana primary root growth and columella stem cell patterns in response to ROS, via direct regulation of PEROXIDASE 28 and RETINOBLASTOMA-RELATED genes.Journal of experimental botany · 2025Article
- Multi-scale mechanisms driving root regeneration: From regeneration competence to tissue repatterning.The Plant journal : for cell and molecular biology · 2024Review
- A predictive model for ethylene-mediated auxin and cytokinin patterning in the Arabidopsis root.Plant communications · 2024Article
- Preponderance of generalized chain functions in reconstructed Boolean models of biological networks.Scientific reports · 2024Article
- Computational analysis of synergism in small networks with different logic.Journal of biological physics · 2023Article
- Live Plant Cell Tracking: Fiji plugin to analyze cell proliferation dynamics and understand morphogenesis.Plant physiology · 2022Article
- The flowering transition pathways converge into a complex gene regulatory network that underlies the phase changes of the shoot apical meristem inFrontiers in plant science · 2022Article
- Review
- Interkingdom Comparison of Threonine Metabolism for Stem Cell Maintenance in Plants and Animals.Frontiers in cell and developmental biology · 2021Review
- Hormonal Regulation of Stem Cell Proliferation at theFrontiers in plant science · 2021Review
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6 authors.
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Abstract
Asymmetric divisions maintain long-term stem cell populations while producing new cells that proliferate and then differentiate. Recent reports in animal systems show that divisions of stem cells can be uncoupled from their progeny differentiation, and the outcome of a division could be influenced by microenvironmental signals. But the underlying system-level mechanisms, and whether this dynamics also occur in plant stem cell niches (SCN), remain elusive. This article presents a cell fate regulatory network model that contributes to understanding such mechanism and identify critical cues for cell fate transitions in the root SCN. Novel computational and experimental results show that the transcriptional regulator SHR is critical for the most frequent asymmetric division previously described for quiescent centre stem cells. A multi-scale model of the root tip that simulated each cell's intracellular regulatory network, and the dynamics of SHR intercellular transport as a cell-cell coupling mechanism, was developed. It revealed that quiescent centre cell divisions produce two identical cells, that may acquire different fates depending on the feedback between SHR's availability and the state of the regulatory network. Novel experimental data presented here validates our model, which in turn, constitutes the first proposed systemic mechanism for uncoupled SCN cell division and differentiation.
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