ArticleNature communications2020
Caspase-11 promotes allergic airway inflammation.
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Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed
4.5field-weighted citation impact, top 4% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
53 citing papers in PubMed, 79 citations in OpenAlex.
- The gasdermin family: from pyroptosis mechanisms to therapeutic targets.Signal transduction and targeted therapy · 2026Review
- VALD-3 Induces GSDME-Dependent Pyroptosis via ROS/JNK/Bax Pathway in Triple-Negative Breast Cancer Cells.Biochemical genetics · 2026Article
- Role of PANoptosis in intestinal diseases and its therapeutic implications.Journal of molecular medicine (Berlin, Germany) · 2026Review
- A Role for Non-Canonical Caspases in Fungal Allergic Airway Disease.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2026Article
- Lipopolysaccharides Drive Proinflammatory Extracellular Vesicle Secretion in Coronary Artery Endothelial Cells via Noncanonical Inflammasome Activation.Cellular and molecular life sciences : CMLS · 2026Article
- Microbial sensing through the non-canonical inflammasome modulates airway type 2 immunity.Frontiers in immunology · 2026Article
- Evidence for Interleukin-17C governing interleukin-17A pathogenicity and promoting asthma endotype switching in bronchiectasis.Nature communications · 2025Article
- Regulation of inflammatory processes by caspases.Nature reviews. Molecular cell biology · 2025Review
- Regulatory Roles of Noncanonical Inflammasomes in Diabetes Mellitus and Diabetes-Associated Complications.International journal of molecular sciences · 2025Review
- New insights into the noncanonical inflammasome point to caspase-4 as a druggable target.Nature reviews. Immunology · 2025Review
- Roles of Pyroptosis in the Progression of Pulpitis and Apical Periodontitis.Journal of inflammation research · 2025Review
- Regulatory Roles of Noncanonical Inflammasomes in Inflammatory Lung Diseases.International journal of molecular sciences · 2024Review
- Pyroptosis, gasdermins and allergic diseases.Allergy · 2024Review
- Exploring caspase functions in mouse models.Apoptosis : an international journal on programmed cell death · 2024Review
- Caspase-5: Structure, Pro-Inflammatory Activity and Evolution.Biomolecules · 2024Review
- Dectin-1 aggravates neutrophil inflammation through caspase-11/4-mediated macrophage pyroptosis in asthma.Respiratory research · 2024Article
- Pyroptosis and polarization of macrophages in septic acute lung injury induced by lipopolysaccharide in mice.Immunity, inflammation and disease · 2024Review
- Article
- Pyroptosis in asthma: inflammatory phenotypes, immune and non-immune cells, and novel treatment approaches.Frontiers in pharmacology · 2024Review
- PANoptosis: Mechanism and Role in Pulmonary Diseases.International journal of molecular sciences · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
22 authors at 4 institutions in 2 countries.
Zbigniew ZasłonaSchool of Biochemistry and Immunology, Trinity Biomedical Sciences Institute (TBSI)Trinity College Dublin, Dublin, Ireland. zaslonaz@tcd.ie.
Ewelina FlisSchool of Biochemistry and Immunology, Trinity Biomedical Sciences Institute (TBSI)Trinity College Dublin, Dublin, Ireland.
Mieszko M WilkSchool of Biochemistry and Immunology, Trinity Biomedical Sciences Institute (TBSI)Trinity College Dublin, Dublin, Ireland.ORCID http://orcid.org/0000-0002-7947-633X
Richard G CarrollSchool of Biochemistry and Immunology, Trinity Biomedical Sciences Institute (TBSI)Trinity College Dublin, Dublin, Ireland.ORCID http://orcid.org/0000-0001-9917-3443
Eva M Palsson-McDermottSchool of Biochemistry and Immunology, Trinity Biomedical Sciences Institute (TBSI)Trinity College Dublin, Dublin, Ireland.
Mark M HughesSchool of Biochemistry and Immunology, Trinity Biomedical Sciences Institute (TBSI)Trinity College Dublin, Dublin, Ireland.
Ciana DiskinSchool of Biochemistry and Immunology, Trinity Biomedical Sciences Institute (TBSI)Trinity College Dublin, Dublin, Ireland.
Kathy BanahanSchool of Biochemistry and Immunology, Trinity Biomedical Sciences Institute (TBSI)Trinity College Dublin, Dublin, Ireland.
Dylan G RyanSchool of Biochemistry and Immunology, Trinity Biomedical Sciences Institute (TBSI)Trinity College Dublin, Dublin, Ireland.
Alexander HooftmanSchool of Biochemistry and Immunology, Trinity Biomedical Sciences Institute (TBSI)Trinity College Dublin, Dublin, Ireland.ORCID http://orcid.org/0000-0002-5412-4012
Alicja MisiakSchool of Biochemistry and Immunology, Trinity Biomedical Sciences Institute (TBSI)Trinity College Dublin, Dublin, Ireland.
Jay KearneySchool of Biochemistry and Immunology, Trinity Biomedical Sciences Institute (TBSI)Trinity College Dublin, Dublin, Ireland.ORCID http://orcid.org/0000-0002-0684-0436
Gunter LochnitDepartment of Biochemistry, Faculty of Medicine, Justus Liebig University, Giessen, Germany.ORCID http://orcid.org/0000-0003-0377-395X
Wilhelm BertramsInstitute for Lung Research, Universities of Giessen and Marburg Lung Center, Philipps-University Marburg, Member of the German Center for Lung Research (DZL), Marburg, Germany.ORCID http://orcid.org/0000-0002-0180-2529
Timm GreulichDepartment of Medicine, Pulmonary and Critical Care Medicine, University Medical Center Giessen and Marburg, Philipps-University, Member of the German Center for Lung Research (DZL), Marburg, Germany.
Bernd SchmeckInstitute for Lung Research, Universities of Giessen and Marburg Lung Center, Philipps-University Marburg, Member of the German Center for Lung Research (DZL), Marburg, Germany.
Oliver J McElvaneyRoyal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland.
Kingston H G MillsSchool of Biochemistry and Immunology, Trinity Biomedical Sciences Institute (TBSI)Trinity College Dublin, Dublin, Ireland.ORCID http://orcid.org/0000-0003-3646-8222
Ed C LavelleSchool of Biochemistry and Immunology, Trinity Biomedical Sciences Institute (TBSI)Trinity College Dublin, Dublin, Ireland.ORCID http://orcid.org/0000-0002-3167-1080
Małgorzata WygreckaDepartment of Biochemistry, Faculty of Medicine, Justus Liebig University, Giessen, Germany.ORCID http://orcid.org/0000-0002-3656-2932
Emma M CreaghSchool of Biochemistry and Immunology, Trinity Biomedical Sciences Institute (TBSI)Trinity College Dublin, Dublin, Ireland.ORCID http://orcid.org/0000-0001-7631-4370
Luke A J O'NeillSchool of Biochemistry and Immunology, Trinity Biomedical Sciences Institute (TBSI)Trinity College Dublin, Dublin, Ireland.ORCID http://orcid.org/0000-0002-4333-2748
Trinity College Dublin · IEGerman Center for Lung Research · DEJustus-Liebig-Universität Gießen · DERoyal College of Surgeons in Ireland · IE
Funding
No grant is acknowledged in the PubMed record.
Abstract
Activated caspase-1 and caspase-11 induce inflammatory cell death in a process termed pyroptosis. Here we show that Prostaglandin E
Indexed as
AnimalsAnti-Inflammatory Agents, Non-SteroidalAsthmaCaspases, InitiatorCells, CulturedDinoprostoneDrug SynergismFemaleHumansIndomethacinMacrophagesMiceMice, Inbred C57BLMice, KnockoutMisoprostolPyroptosisAnti-Inflammatory Agents, Non-SteroidalCasp4 protein, mouseCaspases, InitiatorDinoprostoneIndomethacinMisoprostol
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.