ArticleNeurology2020
Detection of subtle gait disturbance and future fall risk in early multiple sclerosis.
Article in Neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 47 citations in OpenAlex.
- The cost of imbalance: how balance problems drive energy cost of walking in persons with multiple sclerosis.Journal of rehabilitation medicine · 2026Article
- Instrumented Walkway Gait Analysis Predicts Fallers in Neurological Disorders: Identifying Digital Biomarkers for Balance Monitoring.Sensors (Basel, Switzerland) · 2026Article
- Eyes closed single-leg stance test detects subtle sensorimotor decline in early multiple sclerosis.Scientific reports · 2026Article
- Effects of isokinetic exercises on balance, proprioception, quality of life, and kinesiophobia in multiple sclerosis.Neurodegenerative disease management · 2026Article
- Assessing the diagnostic accuracy of symptoms and signs of degenerative cervical myelopathy: A prospective study.Scientific reports · 2025Article
- Gait instability is a more specific predictor of corticospinal tract function than gait speed in clinically stable multiple sclerosis.Scientific reports · 2025Article
- Understanding degenerative cervical myelopathy in musculoskeletal practice.The Journal of manual & manipulative therapy · 2025Review
- Linking Pathogenesis to Fall Risk in Multiple Sclerosis.Archives of internal medicine research · 2025Article
- Exploring the Complexity of Falls in People With Multiple Sclerosis: A Qualitative Study.International journal of MS care · 2024Article
- Sensitive Identification of Asymmetries and Neuromuscular Deficits in Lower Limb Function in Early Multiple Sclerosis.Neurorehabilitation and neural repair · 2024Article
- Uncovering Subtle Gait Deterioration in People with Early-Stage Multiple Sclerosis Using Inertial Sensors: A 2-Year Multicenter Longitudinal Study.Sensors (Basel, Switzerland) · 2023Article
- Multiple sclerosis lesions that impair memory map to a connected memory circuit.Journal of neurology · 2023Article
- Consensus Paper: Ataxic Gait.Cerebellum (London, England) · 2023Article
- Clinical and MRI features of gait and balance disorders in neurodegenerative diseases.Journal of neurology · 2023Review
- Turning and multitask gait unmask gait disturbance in mild-to-moderate multiple sclerosis: Underlying specific cortical thinning and connecting fibers damage.Human brain mapping · 2023Article
- Balance Impairments in People with Early-Stage Multiple Sclerosis: Boosting the Integration of Instrumented Assessment in Clinical Practice.Sensors (Basel, Switzerland) · 2022Article
- Machine learning to investigate superficial white matter integrity in early multiple sclerosis.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2022Article
- Diagnostic usefulness of 10-step tandem gait test for the patient with degenerative cervical myelopathy.Scientific reports · 2021Article
- Dietary factors and MRI metrics in early Multiple Sclerosis.Multiple sclerosis and related disorders · 2021Article
- Depression and cognitive function in early multiple sclerosis: Multitasking is more sensitive than traditional assessments.Multiple sclerosis (Houndmills, Basingstoke, England) · 2021Article
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveTo test the hypothesis that higher-challenge gait and balance tasks are more sensitive than traditional metrics to subtle patient-reported gait dysfunction and future fall risk in early multiple sclerosis (MS).
methodsPersons with early MS (n = 185; ≤5 years diagnosed) reported gait function (MS Walking Scale) and underwent traditional disability metrics (Expanded Disability Status Scale [EDSS], Timed 25 Foot Walk). Patients and healthy controls (n = 50) completed clinically feasible challenge tasks of gait endurance (2-Minute Walk Test), standing balance (NIH Toolbox), and dynamic balance (balance boards; tandem walk on 2 ten-foot boards of different widths, 4.5 and 1.5 in). MRI assessed global and regional brain volumes, total T2 lesion volume (T2LV), infratentorial T2LVs and counts, and cervical cord lesion counts. Falls, near falls, and fall-related injuries were assessed after 1 year. We examined links between all tasks and patient-reported gait, MRI markers, and fall data.
resultsPatients performed worse on higher challenge balance, but not gait, tasks compared with healthy controls. Worse patient-reported gait disturbance was associated with worse performance on all tasks, but only dynamic balance was sensitive to mild patient-reported gait difficulty. Balance tasks were more correlated with MRI metrics than were walking tasks or EDSS score. Thirty percent of patients reported either a fall or near fall after 1 year, with poor dynamic balance as the only task independently predicting falls.
conclusionsBalance plays a leading role in gait dysfunction early in MS. Clinically feasible higher-challenge balance tasks were most sensitive to patient-reported gait, MRI disease markers, and risk of future falls, highlighting potential to advance functional outcomes in clinical practice and trials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.