Evidence map›Paper›PMID 32102971›Full record

ArticleMolecular & cellular proteomics : MCP2020

Chemical Genetics of AGC-kinases Reveals Shared Targets of Ypk1, Protein Kinase A and Sch9.

Michael Plank, Mariya Perepelkina, Markus Müller, Stefania Vaga, Xiaoming Zou, Clélia Bourgoint, Marina Berti, Jacques Saarbach, Steven Haesendonckx, Nicolas Winssinger and 2 more

Abstract read
In one paragraph

Article in Molecular & cellular proteomics : MCP, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Quiescence inAnnual review of genetics · 2022
    Review
  8. Article
  9. Article
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Michael PlankDepartment of Molecular Biology, University of Geneva, CH-1211, Geneva, Switzerland; National Centre of Competence in Research - Chemical Biology, University of Geneva, CH-1211, Geneva, Switzerland. Electronic address: michael.plank@unige.ch.
Mariya PerepelkinaDepartment of Molecular Biology, University of Geneva, CH-1211, Geneva, Switzerland.
Markus MüllerNational Centre of Competence in Research - Chemical Biology, University of Geneva, CH-1211, Geneva, Switzerland; Swiss Institute of Bioinformatics, CH-1015 Lausanne, Switzerland.
Stefania VagaDepartment of Biology, Institute of Molecular Systems Biology, ETH Zürich, CH-8093 Zürich, Switzerland.
Xiaoming ZouDepartment of Molecular Biology, University of Geneva, CH-1211, Geneva, Switzerland.
Clélia BourgointDepartment of Molecular Biology, University of Geneva, CH-1211, Geneva, Switzerland.
Marina BertiDepartment of Molecular Biology, University of Geneva, CH-1211, Geneva, Switzerland.
Jacques SaarbachNational Centre of Competence in Research - Chemical Biology, University of Geneva, CH-1211, Geneva, Switzerland; Department of Organic Chemistry, University of Geneva, CH-1211, Geneva, Switzerland.
Steven HaesendonckxDepartment of Molecular Biology, University of Geneva, CH-1211, Geneva, Switzerland.
Nicolas WinssingerNational Centre of Competence in Research - Chemical Biology, University of Geneva, CH-1211, Geneva, Switzerland; Department of Organic Chemistry, University of Geneva, CH-1211, Geneva, Switzerland.
Ruedi AebersoldDepartment of Biology, Institute of Molecular Systems Biology, ETH Zürich, CH-8093 Zürich, Switzerland; Faculty of Science, University of Zurich, CH-8006, Zurich, Switzerland.
Robbie LoewithDepartment of Molecular Biology, University of Geneva, CH-1211, Geneva, Switzerland; National Centre of Competence in Research - Chemical Biology, University of Geneva, CH-1211, Geneva, Switzerland. Electronic address: Robbie.Loewith@unige.ch.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Protein phosphorylation cascades play a central role in the regulation of cell growth and protein kinases PKA, Sch9 and Ypk1 take center stage in regulating this process in

Indexed as

Amino Acid MotifsAmino Acid SequenceConsensus SequenceCyclic AMP-Dependent Protein KinasesPhosphorylationProtein Kinase InhibitorsProtein Serine-Threonine KinasesProteomeSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsTrehalaseCyclic AMP-Dependent Protein KinasesNTH1 protein, S cerevisiaeProtein Kinase InhibitorsProtein Serine-Threonine KinasesProteomeSaccharomyces cerevisiae ProteinsSCH9 protein, S cerevisiaeTrehalaseYPK1 protein, S cerevisiaeAGC-kinasescell growthchemical geneticsEnzyme inhibitionlabel-free quantificationphosphoproteomeprotein kinasesprotein motifstrehalaseyeast

Identifiers

PMID32102971
PMCPMC7124472

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.