Evidence map›Paper›PMID 32102923›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2020

Interneuron Desynchronization Precedes Seizures in a Mouse Model of Dravet Syndrome.

Conny H Tran, Michael Vaiana, Johan Nakuci, Ala Somarowthu, Kevin M Goff, Nitsan Goldstein, Priya Murthy, Sarah F Muldoon, Ethan M Goldberg

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed
6.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 94 citations in OpenAlex.

  1. Article
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  8. Organellular imagingbioRxiv : the preprint server for biology · 2024
    Article
  9. Review
  10. Article
  11. Heterozygous expression of abioRxiv : the preprint server for biology · 2024
    Article
  12. Article
  13. Ndnf Interneuron Excitability Is Spared in a Mouse Model of Dravet Syndrome.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  14. Article
  15. Review
  16. Review
  17. Review
  18. Article
  19. Seizure Event Detection Using Intravital Two-Photon Calcium Imaging Data.bioRxiv : the preprint server for biology · 2023
    Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 3 countries.

Conny H TranDrexel College of Medicine, Philadelphia, Pennsylvania 19129.
Michael VaianaDepartment of Mathematics.
Johan NakuciNeuroscience Program, University at Buffalo, State University of New York, Buffalo, New York 14260.
Ala SomarowthuDepartment of Pediatrics, Division of Neurology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104.
Kevin M GoffNeuroscience Graduate Group, Perelman School of Medicine at The University of Pennsylvania, Philadelphia, Pennsylvania 19104.
Nitsan GoldsteinNeuroscience Graduate Group, Perelman School of Medicine at The University of Pennsylvania, Philadelphia, Pennsylvania 19104.ORCID 0000-0003-0926-5366
Priya MurthyDepartment of Computer Science and Engineering, University at Buffalo, State University of New York, Buffalo, New York 14260.
Sarah F MuldoonDepartment of Mathematics, goldberge@email.chop.edu smuldoon@buffalo.edu.
Ethan M GoldbergDepartment of Pediatrics, Division of Neurology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, goldberge@email.chop.edu smuldoon@buffalo.edu.ORCID 0000-0002-7404-735X
Children's Hospital of Philadelphia · USUniversity at Buffalo, State University of New York · USUniversity of Pennsylvania · USBuffalo State University · USDrexel University · USHorse Hospital · GB

Funding

Interneuron axonopathy underlies circuit dysfunction in a mouse model of Dravet syndromeR01NS110869 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI ETHAN M GOLDBERG · 2019 to 2026
$3.5M
Dynamic two-photon calcium imaging and optogenetic manipulation of epileptic brain circuits in an experimental model of temporal lobe epilepsyK08NS097633 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI GOLDBERG, ETHAN M · 2016 to 2020
$921k
NINDS NIH HHS K08 NS097633NINDS NIH HHS R01 NS110869
6 · The paper itself

Abstract

Recurrent seizures, which define epilepsy, are transient abnormalities in the electrical activity of the brain. The mechanistic basis of seizure initiation, and the contribution of defined neuronal subtypes to seizure pathophysiology, remains poorly understood. We performed

Indexed as

Action PotentialsAnimalsDisease Models, AnimalEpilepsies, MyoclonicFemaleInterneuronsMaleMiceMice, KnockoutNAV1.1 Voltage-Gated Sodium ChannelSeizuresNAV1.1 Voltage-Gated Sodium ChannelScn1a protein, mouseDravet syndromeepilepsyGABAergic interneuronsNav1.1seizurestwo-photon calcium imaging

Identifiers

PMID32102923
PMCPMC7096149
OpenAlexW3007522902

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.